ArticleCritical care (London, England)2023
Using metabolomics to predict severe traumatic brain injury outcome (GOSE) at 3 and 12 months.
Article in Critical care (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07292766 (Metabolomic Profiling of Patients With Traumatic Brain Injury), which is not on this map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metabolomic Profiling of Patients With Traumatic Brain Injury
Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Exploring the Metabolic Impact of Traumatic Brain Injury in CCI Mouse Models: A Focus on Early and Prolonged Injury Responses.International journal of molecular sciences · 2026Article
- Clinical Prognostic Modeling and Paired Blood-CSF Metabolomic Profiling for Outcome Prediction in Isolated Moderate-to-Severe Traumatic Brain Injury: Implications for Neurocritical Care Management.Journal of clinical medicine · 2026Article
- A cocktail hydrogel promoting the functional interneurons regeneration of human neural progenitor cells for brain injury therapy.Journal of advanced research · 2026Article
- Time-weighted lactate and glucose-lactate ratio outperform static values in ICU mortality prediction after traumatic brain injury: a retrospective cohort study.Journal of intensive care · 2026Article
- Metabolomics of cerebrospinal fluid following traumatic brain injury: Exploration of biomarkers for secondary injuries and severity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Serum Hepcidin Levels are Associated with Poor Outcomes of Patients with Severe Traumatic Brain Injury: A Two-Center Observational Analytical Study.International journal of general medicine · 2026Article
- Blood-Based Biomarkers for Traumatic Brain Injury: A New Era in Diagnosis and Prognosis.International journal of molecular sciences · 2025Review
- The molecular architecture of severe pediatric traumatic brain injury: integrated omics reveal therapeutic pathways.Critical care (London, England) · 2025Observational
- Metabolomics Analysis Reveals Potential Biomarkers for Diffuse Axonal Injury Article Category: Original Work.Neurocritical care · 2025Article
- Restoration of Enzymatic Activity of Energy-Related Proteins in Rats with Traumatic Brain Injury Following Administration of Gamma-Glutamylcysteine Ethyl Ester.Brain sciences · 2025Article
- Interleukin-6 and its association with outcome in traumatic brain injury: a prospective cohort.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Application of Serum NADPH Oxidase 2 Levels for Predicting 180-Day Clinical Outcomes Following Severe Traumatic Brain Injury: A Prospective Cohort Analysis.Brain and behavior · 2025Article
- Identifying early predictive and diagnostic biomarkers and exploring metabolic pathways for sepsis after trauma based on an untargeted metabolomics approach.Scientific reports · 2025Article
- A pilot study on hemodynamically stable isolated chest trauma patients reveals dysregulation of oxidative metabolism.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity.Critical care (London, England) · 2025Article
- Postoperative hyperglycemia in patients with traumatic brain injury: development of a prediction model.Archives of medical science : AMS · 2025Article
- Dynamics of anterior pituitary function in the acute phase of traumatic brain injury: a prospective cohort.Critical care science · 2025Article
- Shared metabolomic signatures for prognostic precision across brain injuries.Brain & spine · 2025Article
- Metabolic pathway dysregulation in diffuse axonal injury: a multimodal biomarker approach for early diagnosis and mechanistic insights.Frontiers in neurology · 2025Article
- Lactate Is a Strong Predictor of Poor Outcomes in Patients with Severe Traumatic Brain Injury.Biomedicines · 2024Article
Corrections and comments
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Authors and funding
8 authors at 15 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrognostication is very important to clinicians and families during the early management of severe traumatic brain injury (sTBI), however, there are no gold standard biomarkers to determine prognosis in sTBI. As has been demonstrated in several diseases, early measurement of serum metabolomic profiles can be used as sensitive and specific biomarkers to predict outcomes.
methodsWe prospectively enrolled 59 adults with sTBI (Glasgow coma scale, GCS ≤ 8) in a multicenter Canadian TBI (CanTBI) study. Serum samples were drawn for metabolomic profiling on the 1st and 4th days following injury. The Glasgow outcome scale extended (GOSE) was collected at 3- and 12-months post-injury. Targeted direct infusion liquid chromatography-tandem mass spectrometry (DI/LC-MS/MS) and untargeted proton nuclear magnetic resonance spectroscopy (
resultsSerum metabolic profiles on days 1 and 4 post-injury were highly predictive (Q DISCUSSION: Metabolomic profiles were strongly associated with the prognosis of GOSE outcome at 3 and 12 months and mortality following sTBI in adults. The metabolic phenotypes on day 4 post-injury were more predictive and significant for predicting the sTBI outcome compared to the day 1 sample. This may reflect the larger contribution of secondary brain injury (day 4) to sTBI outcome. Patients with unfavorable outcomes demonstrated more metabolite changes from day 1 to day 4 post-injury. These findings highlighted increased concentration of neurobiomarkers such as N-acetylaspartate (NAA) and tyrosine, decreased concentrations of ketone bodies, and decreased urea cycle metabolites on day 4 presenting potential metabolites to predict the outcome. The current findings strongly support the use of serum metabolomics, that are shown to be better than clinical data, in determining prognosis in adults with sTBI in the early days post-injury. Our findings, however, require validation in a larger cohort of adults with sTBI to be used for clinical practice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.