Evidence map›Paper›PMID 37480874›Full record

ReviewJACC. Clinical electrophysiology2023

Recurrent Myocarditis in Patients With Desmosomal Pathogenic Variants: Is Self Antigen Presentation the Link?

Jacob J Mayfield, Julius Bogomolovas, M Roselle Abraham, Kathryn Sullivan, Youngho Seo, Farah Sheikh, Melvin Scheinman

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JACC. Clinical electrophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. From inflammation to inheritance: rethinking myocarditis as the first signal of desmosomal cardiomyopathy.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jacob J MayfieldDivision of Cardiology, University of Washington, Seattle, Washington, USA; Division of Cardiology, University of California-San Francisco, San Francisco, California, USA.
Julius BogomolovasDepartment of Medicine, University of California-San Diego, La Jolla, California, USA.
M Roselle AbrahamDivision of Cardiology, University of California-San Francisco, San Francisco, California, USA; Department of Radiology, University of California-San Francisco, San Francisco, California, USA.
Kathryn SullivanDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California-San Francisco, San Francisco, California, USA.
Youngho SeoDepartment of Radiology, University of California-San Francisco, San Francisco, California, USA.
Farah SheikhDepartment of Medicine, University of California-San Diego, La Jolla, California, USA. Electronic address: fasheikh@health.ucsd.edu.
Melvin ScheinmanDivision of Cardiology, University of California-San Francisco, San Francisco, California, USA. Electronic address: Melvin.Scheinman@ucsf.edu.
University of California, San Francisco · USUC San Diego Health System · USUniversity of California San Diego · US

Funding

Uncovering Molecular Targets for Arrhythmogenic Cardiomyopathy TherapeuticsR01HL162369 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHEIKH, FARAH · 2022 to 2025
$2.0M
Uncovering New Functions of CSN6 in Cardiac Desmosomal Biology and DiseaseR01HL142251 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHEIKH, FARAH · 2018 to 2021
$1.6M
Understanding Early Drivers and Therapeutic Targets for Severe Forms of Arrhythmogenic CardiomyopathyR01HL181001 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Farah Sheikh · 2025 to 2026
$1.4M
NHLBI NIH HHS R01 HL142251NHLBI NIH HHS R01 HL162369NHLBI NIH HHS R01 HL181001
6 · The paper itself

Abstract

Myocarditis is frequently associated with viral infections. Increasing evidence points to an association between myocarditis and inherited cardiomyopathies, though it is unclear whether myocarditis is a driver or an accessory. We present a primary vignette and case series highlighting recurrent myocarditis in patients later found to harbor pathogenic desmosomal variants and provide clinical and basic science context, exploring 2 potentially overlapping hypotheses: that stress induces cellular injury and death in structurally abnormal myocytes and that recurrent viral myocardial and truncated desomosomal protein byproducts as 2 hits could lead to loss of immune tolerance and subsequent autoreactivity.

Indexed as

DesmosomesMyocarditisRecurrenceAdultAntigen PresentationFemaleHumansMaleMiddle Agedarrhythmogenic cardiomyopathydesmosomemyocarditis

Identifiers

PMID37480874
PMCPMC12885158
OpenAlexW4384817989

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.