ArticleNeuron2023
A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction.
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Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
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Who cites it
38 citing papers in PubMed, 53 citations in OpenAlex.
- Functional neuroimaging of fatty acid amide hydrolase inhibition in posttraumatic stress disorder: a randomized clinical trial.Translational psychiatry · 2026Trial
- Endocannabinoid and N-acylethanolamine concentrations in hair of female patients with posttraumatic stress disorder - associations with clinical symptoms and outcomes following multimodal trauma-focused inpatient treatment.Translational psychiatry · 2025Trial
- Sterol carrier protein 2 loss reduces anxiety and enhances fear extinction.Journal of affective disorders · 2026Article
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- The basolateral amygdala decodes visceral pain and itch via distinct circuits and molecules.Nature communications · 2026Article
- Oxytocin attenuates fear learning via enhancing somatostatin interneuron-mediated local GABAergic inhibition in the prelimbic cortex.Science advances · 2026Article
- CB1 receptor signaling at the cingulate-striatal circuit is anxiogenic.Nature communications · 2026Article
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- Endocannabinoid modulation of defensive state transitions to innate and learned threat.Psychopharmacology · 2026Article
- Relationships among peri-traumatic circulating endocannabinoids and long-term, negative outcomes following traumatic injury.Psychopharmacology · 2026Article
- Use of Single Prolonged Stress to Model Post-traumatic Stress Disorder in Rodents: What We Found and Where to Next?Current neuropharmacology · 2026Review
- Research Review: What we have learned about the endocannabinoid system in developmental psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Article
- Circuit mechanisms governing endocannabinoid modulation of affective behaviour and stress adaptation.Nature reviews. Neuroscience · 2025Review
- Risk reshapes amygdala representation of choice.bioRxiv : the preprint server for biology · 2025Article
- An Amygdala-hippocampus Circuit for Endocannabinoid Modulation of Anxiety Avoidance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cannabinoid Receptors in the Horse Lateral Nucleus of the Amygdala: A Potential Target for Ameliorating Pain Perception, Stress and Anxiety in Horses.International journal of molecular sciences · 2025Article
- An Alternative Gene Editing Strategy Using a Single AAV Vector.Bio-protocol · 2025Article
- The Involvement of the Endocannabinoid, Glutamatergic, and GABAergic Systems in PTSD.International journal of molecular sciences · 2025Review
- Stress-Induced Endogenous Cannabinoid Signaling Contributes to Fear Generalization.Neuroscience bulletin · 2025Article
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Authors and funding
20 authors at 5 institutions in 2 countries.
Ozge Gunduz-CinarLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA. Electronic address: ozge.gunduzcinar@nih.gov.
Laura I CastilloLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
Maya XiaLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
Elise Van LeerLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
Emma T BrockwayLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
Gabrielle A PollackLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
Farhana YasminNorthwestern Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Olena BukaloLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
Aaron LimogesLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
Sarvar Oreizi-EsfahaniLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
Veronika KondevVanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA.
Rita BáldiNorthwestern Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Ao DongPeking University School of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
Judy Harvey-WhiteLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
Resat CinarLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA; Section on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
George KunosLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
Yulong LiPeking University School of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
Larry S ZweifelDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Sachin PatelNorthwestern Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Andrew HolmesLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA. Electronic address: andrew.holmes@nih.gov.
National Institute on Alcohol Abuse and Alcoholism · USNorthwestern University · USPeking University · CNUniversity of Washington · USVanderbilt University · US
Funding
Mouse models of stress disorders and addictionZIAAA000411 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI HOLMES, ANDREW · 2009 to 2025
$37.7MUniversity of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M2-Arachidonoylglycerol signaling in anxiety, depression, and stress adaptationR01MH107435 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PATEL, SACHIN · 2016 to 2025
$5.0MCentral Amygdala Glutamatergic Circuits in Fear Learning and ExtinctionR01MH119817 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PATEL, SACHIN · 2019 to 2023
$2.6MIntramural NIH HHS ZIA AA000411NIDA NIH HHS P30 DA048736NIMH NIH HHS R01 MH107435NIMH NIH HHS R01 MH119817
Abstract
Preclinical and clinical studies implicate endocannabinoids (eCBs) in fear extinction, but the underlying neural circuit basis of these actions is unclear. Here, we employed in vivo optogenetics, eCB biosensor imaging, ex vivo electrophysiology, and CRISPR-Cas9 gene editing in mice to examine whether basolateral amygdala (BLA)-projecting medial prefrontal cortex (mPFC) neurons represent a neural substrate for the effects of eCBs on extinction. We found that photoexcitation of mPFC axons in BLA during extinction mobilizes BLA eCBs. eCB biosensor imaging showed that eCBs exhibit a dynamic stimulus-specific pattern of activity at mPFC
Indexed as
EndocannabinoidsFearAmygdalaAnimalsExtinction, PsychologicalLearningMicePrefrontal CortexEndocannabinoidsamygdalaanxietyCRISPR-Cas9endocannabinoidextinctionfearGRAB(eCB2.0) biosensoroptogeneticsprefrontal cortexPTSD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.