Evidence map›Paper›PMID 37480755›Full record

ArticleThe Journal of surgical research2023

Associations of Fatty Liver Disease With Recovery After Traumatic Injury.

Katherine Stern, H Laura Aaltonen, Mike Weykamp, Devin Gaskins, Qian Qui, Grant O'Keefe, Alyson Littman, Ken Linnau, Ali Rowhani-Rahbar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Katherine SternDivision of Trauma, Burn & Critical Care, Department of Surgery, Harborview Medical Center, Seattle, Washington; Department of Surgery, University of Washington School of Medicine, Seattle, Washington; University of California San Francisco East Bay General Surgery Residency Program, Oakland, California; University of Washington School of Public Health, Seattle, Washington. Electronic address: sternkatie@gmail.com.
H Laura AaltonenDepartment of Surgery, University of Washington School of Medicine, Seattle, Washington; Department of Radiology, University of Washington School of Medicine, Seattle, Washington.
Mike WeykampDivision of Trauma, Burn & Critical Care, Department of Surgery, Harborview Medical Center, Seattle, Washington; Department of Surgery, University of Washington School of Medicine, Seattle, Washington; University of Washington School of Public Health, Seattle, Washington.
Devin GaskinsDepartment of Surgery, University of Washington School of Medicine, Seattle, Washington.
Qian QuiHarborview Injury Prevention & Research Center, Seattle, Washington.
Grant O'KeefeDivision of Trauma, Burn & Critical Care, Department of Surgery, Harborview Medical Center, Seattle, Washington; Department of Surgery, University of Washington School of Medicine, Seattle, Washington; Harborview Injury Prevention & Research Center, Seattle, Washington.
Alyson LittmanUniversity of Washington School of Public Health, Seattle, Washington; VA Puget Sound Health Care System, Seattle, Washington.
Ken LinnauDivision of Trauma, Burn & Critical Care, Department of Surgery, Harborview Medical Center, Seattle, Washington; Department of Surgery, University of Washington School of Medicine, Seattle, Washington; Department of Radiology, University of Washington School of Medicine, Seattle, Washington.
Ali Rowhani-RahbarUniversity of Washington School of Public Health, Seattle, Washington.
University of Washington · USHarborview Injury Prevention and Research Center · USUniversity of California, San Francisco · US

Funding

Surgery Research Training ProgramT32GM121290 · NIGMS · UNIVERSITY OF WASHINGTON · PI GRANT E O'KEEFE · 2017 to 2026
$2.8M
Protein-enhanced enteral nutrition and metabolomics in critically ill trauma and surgical patientsR01GM127790 · NIGMS · UNIVERSITY OF WASHINGTON · PI O'KEEFE, GRANT E · 2018 to 2021
$1.5M
NIGMS NIH HHS R01 GM127790NIGMS NIH HHS T32 GM121290
6 · The paper itself

Abstract

introductionFatty liver disease (FLD) is associated with systemic inflammation, metabolic disease, and socioeconomic risk factors for poor health outcomes. Little is known on how adults with FLD recover from traumatic injury.

methodsWe studied adults admitted to the intensive care unit of a level 1 trauma center (2016-2020), excluding severe head injury/cirrhosis (N = 510). We measured the liver-spleen attenuation difference in Hounsfield units (HU

resultsFifty-one participants had mild and 29 had moderate/severe FLD. The association of FLD with recovery from SIRS differed according to whether an individual had shock on admission (hazard ratio [HR] = 0.76; 95% confidence interval [CI] 0.55-1.05 with shock; HR = 1.81; 95% CI 1.43-2.28 without shock). Compared to patients with no FLD, the hazard of lactate clearance was similar for mild FLD (HR = 1.04; 95% CI 0.63-1.70) and lower for moderate/severe FLD (HR = 0.40; 95% CI 0.18-0.89).

conclusionsFLD is common among injured adults. Associations of FLD with outcomes after shock and critical illness warrant further study.

Indexed as

Craniocerebral TraumaAdultHumansLactic AcidLiver CirrhosisRisk FactorsSystemic Inflammatory Response SyndromeLactic AcidFatty liver diseaseInflammationInjuryTrauma

Identifiers

PMID37480755
PMCPMC11577254
OpenAlexW4385127899

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.