ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2023
Frailty and Processing Speed Performance at the Cusp of Midlife in CATSLife.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Cognitive dispersion in established adulthood: etiology and implications for cognitive aging.Innovation in aging · 2026Article
- Stability of general cognitive ability from infancy to adulthood: A combined twin and genomic investigation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- How's Your Memory? Convergence of Objective and Subjective Memory Performance Using Ambulatory Assessment in Middle Age.Innovation in aging · 2025Article
- A twin-driven analysis on early aging biomarkers and associations with sitting-time and physical activity.PloS one · 2024Article
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Authors and funding
5 authors.
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Abstract
objectivesFrailty is not an end state of aging, but rather represents physiological vulnerability across multiple systems that unfolds across adulthood. However, examinations of frailty at the midlife transition, and how frailty may impact other age-sensitive traits, such as processing speed (PS), remain scarce. Our research aims were to examine frailty and frailty-speed associations before midlife, a ripe developmental period for healthy aging interventions.
methodsUsing data from the Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (N = 1,215; Mage = 33.23 years; standard deviation = 4.98), we constructed 25-item (FI25) and 30-item (FI30) frailty indices. PS was measured using the Colorado Perceptual Speed task and WAIS-III Digit Symbol (DS) subtest. Multilevel models accounted for clustering among siblings and adjusted for sex, race, ethnicity, adoption status, educational attainment, and age.
resultsReliability of FI measures was apparent from strong intraclass correlations (ICCs) among identical twin siblings, although ICC patterns across all siblings suggested that FI variability may include nonadditive genetic contributions. Higher FI was associated with poorer PS performance but was significant for DS only (BFI25 = -1.17, p = .001, d = -0.12; BFI30 = -1.21, p = .001, d = -0.12). Furthermore, the negative frailty-DS association was moderated by age (BFI25×age = -0.14, p = .042; BFI30×age=-0.19, p = .008) where increasingly worse performance with higher frailty emerged at older ages. DISCUSSION: Frailty is evident before midlife and associated with poorer PS, an association that magnifies with age. These findings help elucidate the interrelationship between indicators of frailty and cognitive performance for adults approaching midlife, an understudied period within life-span development.
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Registered trials
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