Evidence map›Paper›PMID 37480466›Full record

ReviewAdvances in neurobiology2023

TiO

Lars Wiklund, Aruna Sharma, Dafin F Muresanu, Zhiqiang Zhang, Cong Li, Z Ryan Tian, Anca D Buzoianu, José Vicente Lafuente, Ala Nozari, Lianyuan Feng and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Journal of proteome research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 5 countries.

Lars WiklundDepartment of Surgical Sciences, International Experimental Central Nervous System Injury & Repair (IECNSIR), Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.
Aruna SharmaDepartment of Surgical Sciences, International Experimental Central Nervous System Injury & Repair (IECNSIR), Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Aruna.Sharma@surgsci.uu.se.
Dafin F MuresanuDepartment of Clinical Neurosciences, University of Medicine & Pharmacy, Cluj-Napoca, Romania.
Zhiqiang ZhangDepartment of Neurosurgery, Chinese Medicine Hospital of Guangdong Province; The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Yuexiu District, China.
Cong LiDepartment of Neurosurgery, Chinese Medicine Hospital of Guangdong Province; The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Yuexiu District, China.
Z Ryan TianDepartment of Chemistry & Biochemistry, University of Arkansas, Fayetteville, AR, USA.
Anca D BuzoianuDepartment of Clinical Pharmacology and Toxicology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
José Vicente LafuenteLaNCE, Department of Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain.
Ala NozariAnesthesiology & Intensive Care, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA.
Lianyuan FengDepartment of Neurology, Bethune International Peace Hospital, Zhongshan Road (West), Shijiazhuang, Hebei Province, China.
Hari Shanker SharmaDepartment of Surgical Sciences, International Experimental Central Nervous System Injury & Repair (IECNSIR), Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Sharma@surgsci.uu.se.
Uppsala University Hospital · SEGuangzhou University of Chinese Medicine · CNBethune International Peace Hospital · CNBoston University · USIuliu Hațieganu University of Medicine and Pharmacy · ROResearch Institute for Analytical Instrumentation · ROUniversity of Arkansas at Fayetteville · USUniversity of the Basque Country · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Military personnel during combat or peacekeeping operations are exposed to extreme climates of hot or cold environments for longer durations. Spinal cord injury is quite common in military personnel following central nervous system (CNS) trauma indicating a possibility of altered pathophysiological responses at different ambient temperatures. Our previous studies show that the pathophysiology of brain injury is exacerbated in animals acclimated to cold (5 °C) or hot (30 °C) environments. In these diverse ambient temperature zones, trauma exacerbated oxidative stress generation inducing greater blood-brain barrier (BBB) permeability and cell damage. Extracts of Ginkgo biloba EGb-761 and BN-52021 treatment reduces brain pathology following heat stress. This effect is further improved following TiO

Indexed as

BilobalidesGinkgo bilobaNeuroprotective AgentsSpinal Cord InjuriesAmino AcidsAnimalsChinaCold TemperatureCyclopentanesDrug Delivery SystemsFuransGinkgo ExtractGinkgolidesLactonesNanowiresPlant ExtractsAmino AcidsbilobalideBilobalidescerebrolysinCyclopentanesFuransGinkgo biloba extractGinkgo Extractginkgolide BGinkgolidesLactonesNeuroprotective AgentsPlant ExtractsTitaniumtitanium dioxideBloodCold environmentCord pathologyEGb-761, BN-52021Nanowired deliveryNeuroprotectionspinal cord barrierSpinal cord edemaSpinal cord injury

Identifiers

PMID37480466
OpenAlexW4385146629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.