Evidence map›Paper›PMID 37480410›Full record

Observational studyLung2023

Early Detection of Aspergillus Species in Lower Respiratory Tract is Associated with Higher Mortality in Viral Community-Acquired Pneumonia: A Multicenter Prospective Cohort Study in China.

Lu Yin, Ying Zhang, Yali Zheng, Qiongzhen Luo, Lili Zhao, Wentao Ni, Yu Xu, Zhancheng Gao

Registry-linked trialAbstract readObservational StudyMulticenter Study
PubMed Publisher
In one paragraph

Observational study in Lung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03093220 (Molecular Typing of Adult Community-acquired Pneumonia in China), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03093220 unknown statusnot on this map

Molecular Typing of Adult Community-acquired Pneumonia in China

TypeobservationalSponsorPeking University People's HospitalRan2017 to 2018Enrolled500ConditionsRespiratory Infections, Genetic Disorder, Community-Acquired Infections, Host-Pathogen Interactions
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Detection ofFrontiers in cellular and infection microbiology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lu Yin *Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, No.11, Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Ying Zhang *Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, No.11, Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Yali ZhengDepartment of Respiratory and Critical Care and Sleep Medicine, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361101, China.
Qiongzhen LuoDepartment of Respiratory and Critical Care Medicine, Beijing Tsinghua Changgung Hospital, Beijing, 102218, China.
Lili ZhaoDepartment of Respiratory and Critical Care Medicine, Peking University People's Hospital, No.11, Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Wentao NiDepartment of Respiratory and Critical Care Medicine, Peking University People's Hospital, No.11, Xizhimen South Street, Xicheng District, Beijing, 100044, China. wentao.qingdao@163.com.
Yu XuDepartment of Respiratory and Critical Care Medicine, Beijing Jishuitan Hospital, No. 31, Xinjiekou East Street, Xicheng District, Beijing, 100035, China. xuyu@bjmu.edu.cn.
Zhancheng GaoDepartment of Respiratory and Critical Care Medicine, Peking University People's Hospital, No.11, Xizhimen South Street, Xicheng District, Beijing, 100044, China. zcgao@bjmu.edu.cn.ORCID 0000-0001-7415-1416
Peking University · CNBeijing Tsinghua Chang Gung Hospital · CNXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCommunity-acquired pneumonia (CAP) is a leading cause of adult mortality worldwide and poses a significant global burden. Previous studies have indicated a tendency for viral pneumonia, particularly severe influenza virus pneumonia, to be complicated by Aspergillus superinfection. However, the clinical features and prognostic implications of Aspergillus detection in early-onset viral CAP remain unclear.

methodsWe conducted a prospective multicenter observational cohort study in China involving CAP patients. Adult patients with CAP from six hospitals were enrolled between January 2017 and October 2018. Within 72 h of admission, lower respiratory tract specimens, including sputum and alveolar lavage fluid, were collected. Comprehensive pathogenic testing, utilizing molecular biology techniques, was performed on the collected specimens, encompassing bacteria, atypical pathogens, viruses, and fungi. Patient clinical data were collected through a unified electronic medical record website system.

resultsA total of 382 adult CAP patients were included in the study. The viral detection rate was 38% (145/382), with Aspergillus identified in 11.0% (16/145) of viral CAP cases. Mortality among Aspergillus-positive patients was significantly higher (25%, 4/16) compared to Aspergillus-negative patients (5.4%, 7/129) in viral CAP (P = 0.021). Multivariable logistic regression models demonstrated that the presence of Aspergillus at admission might increase the mortality risk in viral CAP [OR (95%CI) = 7.34 (0.92-58.65), P = 0.06]. Furthermore, Aspergillus-positive patients exhibited a significantly lower lymphocyte count than Aspergillus-negative patients (P = 0.047).

conclusionPositive detection of Aspergillus in lower respiratory tract specimens might be associated with higher mortality in early-onset viral CAP.

trial registrationClinicalTrials.gov, NCT03093220. Registered retrospectively on 28 March 2017.

Indexed as

Community-Acquired InfectionsInfluenza, HumanPneumonia, ViralAdultAspergillusChinaHumansProspective StudiesRespiratory SystemRetrospective StudiesAspergillus infectionCommunity-acquired pneumoniaLymphopeniaPulmonary aspergillosisRisk factorViral pneumonia

Identifiers

PMID37480410
OpenAlexW4385075512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.