ArticleEuropean stroke journal2023
Symptomatic Carotid Atheroma Inflammation Lumen-stenosis score compared with Oxford and Essen risk scores to predict recurrent stroke in symptomatic carotid stenosis.
Sarah Gorey, John J McCabe, Pol Camps-Renom, Nicola Giannotti, Jonathan P McNulty, Mary Barry, Tim Cassidy, Simon Cronin, Eamon Dolan, Alejandro Fernández-León and 7 more
Open access · hybridAbstract read
In one paragraphArticle in European stroke journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
17 authors at 8 institutions in 3 countries.
Sarah GoreyHealth Research Board (HRB), Stroke Clinical Trials Network Ireland (SCTNI), Dublin, Ireland.ORCID 0000-0001-8079-7969 John J McCabeHealth Research Board (HRB), Stroke Clinical Trials Network Ireland (SCTNI), Dublin, Ireland.ORCID 0000-0003-2029-1303 Pol Camps-RenomDepartment of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona (Department of Medicine), Barcelona, Spain.ORCID 0000-0001-6587-6271 Jonathan P McNultySchool of Medicine, University College Dublin, Dublin, Ireland.
Mary BarryDepartment of Vascular Surgery, St Vincent's University Hospital, Dublin, Ireland.
Tim CassidyHealth Research Board (HRB), Stroke Clinical Trials Network Ireland (SCTNI), Dublin, Ireland.
Simon CroninHealth Research Board (HRB), Stroke Clinical Trials Network Ireland (SCTNI), Dublin, Ireland.
Eamon DolanHealth Research Board (HRB), Stroke Clinical Trials Network Ireland (SCTNI), Dublin, Ireland.
Alejandro Fernández-LeónDepartment of Nuclear Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Shane FoleySchool of Medicine, University College Dublin, Dublin, Ireland.
Joseph HarbisonStroke Service, Department of Geriatric Medicine, St James' Hospital, Dublin, Ireland.
Martin O'ConnellSchool of Medicine, University College Dublin, Dublin, Ireland.
David J WilliamsHealth Research Board (HRB), Stroke Clinical Trials Network Ireland (SCTNI), Dublin, Ireland.
Michael MarnaneHealth Research Board (HRB), Stroke Clinical Trials Network Ireland (SCTNI), Dublin, Ireland.
Joan Martí-FabregasDepartment of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona (Department of Medicine), Barcelona, Spain.ORCID 0000-0001-9229-8649 Peter J KellyHealth Research Board (HRB), Stroke Clinical Trials Network Ireland (SCTNI), Dublin, Ireland.ORCID 0000-0003-4772-6565 University College Dublin · IEUniversitat Autònoma de Barcelona · ESConnolly Hospital Blanchardstown · IEHospital de Sant Pau · ESRoyal College of Surgeons in Ireland · IESt. James's Hospital · IESt. Vincent's University Hospital · IEUniversity College Cork · IE
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundThe Oxford Carotid Stenosis tool (OCST) and Essen Stroke Risk Score (ESRS) are validated to predict recurrent stroke in patients with and without carotid stenosis. The Symptomatic Carotid Atheroma Inflammation Lumen stenosis (SCAIL) score combines stenosis and plaque inflammation on fluorodeoxyglucose positron-emission tomography ( PATIENTS AND
methodsWe pooled three prospective cohort studies of patients with recent (<30 days) non-severe ischaemic stroke/TIA and internal carotid artery stenosis (>50%). All patients had carotid
resultsOf 212 included patients, 16 post-PET ipsilateral recurrent strokes occurred in 343 patient-years follow-up (median 42 days (IQR 13-815)).Baseline SCAIL predicted recurrent stroke (unadjusted hazard ratio [HR] 1.96, CI 1.20-3.22,
conclusionsSCAIL predicted recurrent stroke, had discrimination better than chance, and improved the prognostic utility of ESRS, suggesting that measuring plaque inflammation may improve risk stratification in carotid stenosis.
Indexed as
Brain IschemiaCarotid StenosisPlaque, AtheroscleroticStrokeCerebral InfarctionConstriction, PathologicFluorodeoxyglucose F18HumansInflammationPositron Emission Tomography Computed TomographyProspective StudiesRisk FactorsFluorodeoxyglucose F18atherosclerosiscarotid stenosisinflammationPredictionrecurrent strokevascular inflammation
Identifiers
PMID37480278
PMCPMC10683720
OpenAlexW4385063972
What OpenQuestion holds
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LicenceCC BY
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