Evidence map›Paper›PMID 37480140›Full record

ArticleJournal of ovarian research2023

Correlation between abnormal energy metabolism of ovarian granulosa cells and in vitro fertilization-embryo transfer outcomes in patients with polycystic ovary syndrome and obesity.

Ya-Kun Zhao, Ya-Na Gao, Ling-Chao Wang, Jing Wang, Gai-Jing Wang, Hong-Li Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ya-Kun Zhao *Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, NO. 212 Yuhua East Road, Lianchi District, Baoding, 071000, Hebei, China.
Ya-Na Gao *Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, NO. 212 Yuhua East Road, Lianchi District, Baoding, 071000, Hebei, China.
Ling-Chao Wang66350 Medical Company of PLA, Baoding, 071000, Hebei, China.
Jing WangDepartment of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, NO. 212 Yuhua East Road, Lianchi District, Baoding, 071000, Hebei, China. wangjingwj91@126.com.
Gai-Jing WangDepartment of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, NO. 212 Yuhua East Road, Lianchi District, Baoding, 071000, Hebei, China.
Hong-Li WuDepartment of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, NO. 212 Yuhua East Road, Lianchi District, Baoding, 071000, Hebei, China.
Affiliated Hospital of Hebei University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextGranulosa cells (GCs) that surround oocytes in mammalian reproduction play an active role in oocyte differentiation through proliferation and energy production.

aimsThis study aimed to investigate the characteristics of the energy metabolism of ovarian GCs and the influence of GCs on the early embryonic development in polycystic ovary syndrome (PCOS).

methodsThe clinical characteristics and in vitro fertilization-embryo transfer treatment outcomes of 39 patients with PCOS and 68 patients with simple tubal factor infertility who underwent controlled ovarian hyperstimulation were analyzed and summarized. The mitochondrial function and glucose metabolism level of the GCs were determined, as well as the content of oxidative stress markers in the follicular fluid (FF) of patients with and without PCOS. KEY

resultsWhen compared to the non-PCOS group, patients with PCOS had a significantly increased number of retrieved oocytes but a significantly decreased number of high-quality embryos, available embryos, and high-quality blastocyst formation (P < 0.05). Furthermore, the mitochondrial membrane potential, adenosine triphosphate level, and mitochondrial DNA (mtDNA) copy number decreased in the GCs, whereas the levels of reactive oxygen species increased (P < 0.01). The levels of malondialdehyde and 8-oxo-deoxyguanosine (8-OHdG) in the follicular fluid (FF) of the patients with PCOS were higher than those of the control group (P < 0.05), and superoxide dismutase was increased by compensation (P < 0.05). In the PCOS group, the expressions of GLUT1, LDHA, and PFKP were lower than those in the non-PCOS group, and glucose levels were higher.

conclusionsThe low oocyte competence of PCOS may be associated with mitochondrial dysfunction and abnormal glycolysis. IMPLICATIONS: This research offers explanations for the possible connections influencing human ovarian folliculogenesis.

Indexed as

Polycystic Ovary SyndromeEmbryo TransferEnergy MetabolismFemaleFertilization in VitroFollicular FluidGranulosa CellsHumansObesityPregnancyGlycolysisGranulosa cellsMitochondrial functionsPolycystic ovary syndrome

Identifiers

PMID37480140
PMCPMC10362761
OpenAlexW4385064336

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.