ArticleBMC complementary medicine and therapies2023
Authentication of milk thistle commercial products using UHPLC-QTOF-ESI + MS metabolomics and DNA metabarcoding.
Article in BMC complementary medicine and therapies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Mass Spectrometric Fingerprinting to Detect Fraud and Herbal Adulteration in Plant Food Supplements.Molecules (Basel, Switzerland) · 2025Article
- Multi-method survey rediscovers critically endangered species and strengthens Madagascar's freshwater fish conservation.Scientific reports · 2024Article
- Milk thistle protects against non-alcoholic fatty liver disease induced by dietary thermally oxidized tallow.Heliyon · 2024Article
- Harnessing eDNA metabarcoding to investigate fish community composition and its seasonal changes in the Oslo fjord.Scientific reports · 2024Article
- Investigation ofPlants (Basel, Switzerland) · 2024Article
- Three-tiered authentication of herbal traditional Chinese medicine ingredients used in women's health provides progressive qualitative and quantitative insight.Frontiers in pharmacology · 2024Article
- Detecting and Profiling of Milk Thistle Metabolites in Food Supplements: A Safety-Oriented Approach by Advanced Analytics.Metabolites · 2023Review
- Complementary authentication of Chinese herbal products to treat endometriosis using DNA metabarcoding and HPTLC shows a high level of variability.Frontiers in pharmacology · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMilk thistle is one of the most popular hepatoprotectants, and is often sold in combination with other ingredients. Botanical supplements are known to be vulnerable to contamination and adulteration, and emerging technologies show promise to improve their quality control.
methodsUntargeted and semi-targeted metabolomics based on UHPLC-QTOF-ESI
resultsUntargeted metabolomics separated 217 molecules and by multivariate analysis the discrimination between the different preparations was established. The semi-targeted metabolomics focused on 63 phytochemicals, mainly silymarin flavonolignans and flavonoids, that may be considered as putative biomarkers of authenticity. All formulations contained molecules from silymarin complexes at different levels. The quantitative evaluation of silybins was done using in parallel UV spectrometry and UHPLC-QTOF-ESI
conclusionOur study emphasizes that combining spectroscopic, chromatographic, and genetic techniques bring complementary information to guarantee the quality of the botanical formulations.
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Registered trials
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