Evidence map›Paper›PMID 37480120›Full record

Observational studyVirology journal2023

Prevalence of hepatitis C virus among patients with arthralgia: is it logic for screening?

Arwa Mohammed Othman, Asma'a Ahmed Al-Hnhna, Belques Sharaf Al-Huraibi, Rowa Mohammed Assayaghi, Talal Yahya Al-Qahtani, Kamal Hamoud Jahzar, Marwan Mohammed Al-Huthaifi

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Virology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Arwa Mohammed OthmanMicrobiology and Immunology Department, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen. arwaothman@hotmail.com.ORCID 0000-0001-5893-2247
Asma'a Ahmed Al-HnhnaGastroenterology and Hepatology, Medicine department, 21 September University, Sana'a, Yemen.
Belques Sharaf Al-HuraibiMicrobiology and Immunology Department, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a-Yemen, Yemen.
Rowa Mohammed AssayaghiMicrobiology and Immunology Department, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a-Yemen, Yemen.
Talal Yahya Al-QahtaniMicrobiology and Immunology Department, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a-Yemen, Yemen.
Kamal Hamoud JahzarBiomedical sciences department, Lebanese International University, Sana'a Compass, Yemen.
Marwan Mohammed Al-HuthaifiMicrobiology and Immunology Department, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a-Yemen, Yemen.
Sana'a University · YELebanese International University · YE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatitis C virus (HCV) is well-known to be associated with multiple extrahepatic manifestations such as arthralgia, myalgia, arthritis, and vasculitis. Many studies reported frequent rheumatologic manifestations among patients infected by HCV. The purpose of this study was to determine the prevalence of HCV among chronic unexplained arthralgia patients in order to aid in the early detection and treatment of silent HCV infection.

methodsThis study was a cross-sectional observational study conducted from July 2020 to May 2022. It included 145 individuals suffering from chronic unexplained arthralgia, with vast majority having oligoarticular joint pain (110, 75.9%). They were 103 (71%) females and 42 (29%) males. Serum samples from all patients were examined for the presence of anti-HCV antibodies using a rapid immunochromatographic assay. Seropositive samples were further examined using polymerase chain reaction (PCR) for detection of HCV RNA to confirm HCV infection.

resultsOut of 145 patients who complained of arthralgia, seven patients tested positive for anti-HCV with a seroprevalence of 4.8% while five patients tested positive for HCV-RNA with a molecular prevalence of 3.4%. All positive patients were males (11.9%) with high statistical significance (χ

conclusionsThe prevalence of HCV was high among males who complained of arthralgia. Patients with arthralgia, especially male patients, are recommended to perform HCV screening test.

Indexed as

HepacivirusHepatitis CArthralgiaCross-Sectional StudiesFemaleHumansLogicMalePrevalenceRNASeroepidemiologic StudiesRNAArthralgiaChronic hepatitis CExtrahepatic manifestationsHepatitis C virus

Identifiers

PMID37480120
PMCPMC10360329
OpenAlexW4385064380

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.