ArticleEnvironmental health : a global access science source2023
Environmental exposures in early-life and general health in childhood.
Article in Environmental health : a global access science source, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Impact of War on Asthma, a Systematic Review and Meta-Analysis: An EAACI Task Force Report.Allergy · 2026Pooled it
- Beyond genetics: how environmental stressors drive pediatric hypertension risk.Pediatric nephrology (Berlin, Germany) · 2026Review
- Assessing environmental exposures in children: toward a comprehensive exposome approach.Pediatric research · 2026Review
- Article
- Advancing child health: forecasting the next great research achievements.Pediatric research · 2026Article
- Environmental Radon Exposure and Inflammatory Responses in Children and Adolescents: Evidence from a High-Radon Region in Kazakhstan.Biomedicines · 2026Article
- Interactive Effects of Genetic Susceptibility and Early-Life Tobacco Smoke Exposure on the Asthma-Eczema Complex Phenotype in Children: 6-Year Follow-Up Case-Control Study.International journal of molecular sciences · 2025Article
- The promise and challenges of exposomics in child health research.Pediatric research · 2025Review
- The German Center for Child and Adolescent Health - A new structure for translational research in pediatrics shaping the health of children today and future generations.Molecular and cellular pediatrics · 2025Article
- Exposed and Vulnerable: Sources and Health Implications of Chemical Exposures in Neonatal, Pediatric, and Cardiac Intensive Care Units.Current environmental health reports · 2025Review
- Early life factors and variation in adult kidney function in the Swedish LifeGene cohort.Scientific reports · 2025Article
- Clusters and associations of adverse neonatal events with adult risk of multimorbidity: A secondary analysis of birth cohort data.PloS one · 2025Article
- Tributyl phosphate as a type of environmental endocrine disruptor associated with liver fibrosis: insights from NHANES andFrontiers in toxicology · 2025Article
- Effects of higher dietary acid load: a narrative review with special emphasis in children.Pediatric nephrology (Berlin, Germany) · 2025Review
- Maternal Nutrition, Toxicants, and Epigenetic Programming of Obesity Across Generations.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Maternal occupational exposures during early stages of pregnancy and adverse birth outcomes in the NINFEA birth-cohort.PloS one · 2025Article
- Subpopulations of children with multiple chronic health outcomes in relation to chemical exposures in the ECHO-PATHWAYS consortium.Environment international · 2024Article
- Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort.Environmental health : a global access science source · 2024Article
- The protective effect of the intestinal microbiota in type-1 diabetes in NOD mice is limited to a time window in early life.Frontiers in endocrinology · 2024Article
- Beyond the single-outcome approach: A comparison of outcome-wide analysis methods for exposome research.Environment international · 2023Article
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26 authors.
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Abstract
backgroundEarly-life environmental exposures are suspected to be involved in the development of chronic diseases later in life. Most studies conducted so far considered single or few exposures and single-health parameter. Our study aimed to identify a childhood general health score and assess its association with a wide range of pre- and post-natal environmental exposures.
methodsThe analysis is based on 870 children (6-12 years) from six European birth cohorts participating in the Human Early-Life Exposome project. A total of 53 prenatal and 105 childhood environmental factors were considered, including lifestyle, social, urban and chemical exposures. We built a general health score by averaging three sub-scores (cardiometabolic, respiratory/allergy and mental) built from 15 health parameters. By construct, a child with a low score has a low general health status. Penalized multivariable regression through Least Absolute Shrinkage and Selection Operator (LASSO) was fitted in order to identify exposures associated with the general health score.
findingsThe results of LASSO show that a lower general health score was associated with maternal passive and active smoking during pregnancy and postnatal exposure to methylparaben, copper, indoor air pollutants, high intake of caffeinated drinks and few contacts with friends and family. Higher child's general health score was associated with prenatal exposure to a bluespace near residency and postnatal exposures to pets, cobalt, high intakes of vegetables and more physical activity. Against our hypotheses, postnatal exposure to organochlorine compounds and perfluorooctanoate were associated with a higher child's general health score.
conclusionBy using a general health score summarizing the child cardiometabolic, respiratory/allergy and mental health, this study reinforced previously suspected environmental factors associated with various child health parameters (e.g. tobacco, air pollutants) and identified new factors (e.g. pets, bluespace) warranting further investigations.
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