Evidence map›Paper›PMID 37479946›Full record

SynthesisJournal of assisted reproduction and genetics2023

Systematic review and meta-analysis: does pre-implantation genetic testing for aneuploidy at the blastocyst stage improve live birth rate?

Lorraine S Kasaven, Diana Marcus, Efstathios Theodorou, Benjamin P Jones, Srdjan Saso, Roy Naja, Paul Serhal, Jara Ben-Nagi

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of assisted reproduction and genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  5. The effect of laser-assisted hatching on clinical outcomes of frozen-thawed embryo transfer at different embryo ages.European journal of obstetrics & gynecology and reproductive biology: X · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lorraine S KasavenDepartment of Cancer and Surgery, Imperial College London, Exhibition Rd, South Kensington, London, SW7 2BX, UK. lk226@doctors.org.uk.ORCID http://orcid.org/0000-0002-1752-5220
Diana MarcusDepartment of Cancer and Surgery, Imperial College London, Exhibition Rd, South Kensington, London, SW7 2BX, UK.
Efstathios TheodorouCentre for Reproductive and Genetic Health, Great Portland Street, London, W1W 5QS, UK.
Benjamin P JonesDepartment of Cancer and Surgery, Imperial College London, Exhibition Rd, South Kensington, London, SW7 2BX, UK.
Srdjan SasoDepartment of Cancer and Surgery, Imperial College London, Exhibition Rd, South Kensington, London, SW7 2BX, UK.
Roy NajaInstitute for Women's Health, University College London, 84-86 Chenies Mews, London, WC1E 6HU, UK.
Paul SerhalCentre for Reproductive and Genetic Health, Great Portland Street, London, W1W 5QS, UK.
Jara Ben-NagiDepartment of Cancer and Surgery, Imperial College London, Exhibition Rd, South Kensington, London, SW7 2BX, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo establish if preimplantation genetic testing for aneuploidy (PGT-A) at the blastocyst stage improves the composite outcome of live birth rate and ongoing pregnancy rate per embryo transfer compared to conventional morphological assessment.

methodsA systematic literature search was conducted using PubMed, EMBASE and Cochrane database from 1st March 2000 until 1st March 2022. Studies comparing reproductive outcomes following in vitro fertilisation using comprehensive chromosome screening (CCS) at the blastocyst stage with traditional morphological methods were evaluated.

resultsOf the 1307 citations identified, six randomised control trials (RCTs) and ten cohort studies fulfilled the inclusion criteria. The pooled data identified a benefit between PGT-A and control groups in the composite outcome of live birth rate and ongoing pregnancy per embryo transfer in both the RCT (RR 1.09, 95% CI 1.02-1.16) and cohort studies (RR 1.50, 95% CI 1.28-1.76). Euploid embryos identified by CCS were more likely to be successfully implanted amongst the RCT (RR 1.20, 95% CI 1.10-1.31) and cohort (RR 1.69, 95% CI 1.29-2.21) studies. The rate of miscarriage per clinical pregnancy is also significantly lower when CCS is implemented (RCT: RR 0.73, 95% CI 0.56-0.96 and cohort: RR 0.48, 95% CI 0.32-0.72).

conclusionsCCS-based PGT-A at the blastocyst biopsy stage increases the composite outcome of live births and ongoing pregnancies per embryo transfer and reduces the rate of miscarriage compared to morphological assessment alone. In view of the limited number of studies included and the variation in methodology between studies, future reviews and analyses are required to confirm these findings.

Indexed as

Abortion, SpontaneousBirth RateAneuploidyBlastocystFemaleGenetic TestingHumansPregnancyBlastocystInfertilityLive birth rateMeta-analysisOngoing pregnancy ratePre-implantation genetic testing for aneuploidySystematic review

Identifiers

PMID37479946
PMCPMC10504192

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.