Evidence map›Paper›PMID 37479894›Full record

ReviewHuman genetics2023

Genomics and inclusion of Indigenous peoples in high income countries.

Kylie Gwynne, Shirley Jiang, Robertson Venema, Vita Christie, Tiffany Boughtwood, Marida Ritha, John Skinner, Nyesa Ali, Boe Rambaldini, Tom Calma

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Human genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Kylie GwynneDjurali Centre for Aboriginal and Torres Strait Islander Education and Research (Formerly Known as Poche Centre for Indigenous Health), Macquarie University, Walanga Muru Building, 6 First Walk, Sydney, NSW, 2113, Australia.
Shirley JiangUniversity of Toronto, 27 King's College Circuit, Toronto, Canada.
Robertson VenemaUniversity of Toronto, 27 King's College Circuit, Toronto, Canada.
Vita ChristieDjurali Centre for Aboriginal and Torres Strait Islander Education and Research (Formerly Known as Poche Centre for Indigenous Health), Macquarie University, Walanga Muru Building, 6 First Walk, Sydney, NSW, 2113, Australia. vita.christie@mq.edu.au.ORCID http://orcid.org/0000-0003-3887-8305
Tiffany BoughtwoodAustralian Genomics, 50 Flemington Rd, Parkville, VIC, 3052, Australia.
Marida RithaDjurali Centre for Aboriginal and Torres Strait Islander Education and Research (Formerly Known as Poche Centre for Indigenous Health), Macquarie University, Walanga Muru Building, 6 First Walk, Sydney, NSW, 2113, Australia.
John SkinnerDjurali Centre for Aboriginal and Torres Strait Islander Education and Research (Formerly Known as Poche Centre for Indigenous Health), Macquarie University, Walanga Muru Building, 6 First Walk, Sydney, NSW, 2113, Australia.
Nyesa AliMurdoch Children's Research Institute, Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC, 3052, Australia.
Boe RambaldiniDjurali Centre for Aboriginal and Torres Strait Islander Education and Research (Formerly Known as Poche Centre for Indigenous Health), Macquarie University, Walanga Muru Building, 6 First Walk, Sydney, NSW, 2113, Australia.
Tom CalmaDjurali Centre for Aboriginal and Torres Strait Islander Education and Research (Formerly Known as Poche Centre for Indigenous Health), Macquarie University, Walanga Muru Building, 6 First Walk, Sydney, NSW, 2113, Australia.
Australian Institute of Aboriginal and Torres Strait Islander Studies · AURoyal Children's Hospital · AUUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genomics research related to Indigenous people has been at worst exploitative and at best, retrospectively on a journey to improve effective engagement of Indigenous individuals and communities. Genomics can positively impact all stages of clinical management, and to improve genomic effectiveness researchers aggregate genomic data from diverse global sub-populations, such as shared ancestry groupings, as people within these groupings will have a greater proportion of shared DNA traits. While genomics is already being used worldwide to improve lives, its utility and effectiveness has not been maximized for individuals with Indigenous ancestry. Several large datasets of human genetic variation have been made publicly available, of which the most widely used is the Genome Aggregation Database (gnomAD), but none of these databases currently contain any population-specific data for Indigenous populations. There are many reasons why Indigenous people have been largely left out of genomics research and, because of this, miss out on the benefits offered. It is also clear that if research is to be effective, it needs to be done 'with' and not 'on' Indigenous communities. This systematic review of the literature regarding Indigenous peoples (in high income countries) and genomics aims to review the existing literature and identify areas of strength and weakness in study design and conduct, focusing on the effectiveness of Indigenous community engagement.

Indexed as

GenomicsIndigenous PeoplesDatabases, FactualDeveloped CountriesHumansRetrospective Studies

Identifiers

PMID37479894
PMCPMC10449672
OpenAlexW4385064112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.