ArticleThe ISME journal2023
Metabolism of plant-derived toxins from its insect host increases the success of the entomopathogenic fungus Beauveria bassiana.
Article in The ISME journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Potential biocontrol efficacy of native Beauveria bassiana against diamondback moth (Plutella xylostella) and aphid (Brevicoryne brassicae) in cabbage.Archives of microbiology · 2026Article
- Glucosinolate hydrolysis products suppress entomopathogenic nematodes in vitro but do not protect sequestering flea beetle larvae in vivo.Pest management science · 2026Article
- Detoxification of conifer antimicrobial defenses promotes entomopathogenic fungus infection of bark beetles.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- T7-Synthesized Double-Stranded RNA Mimicking miR-71 Induces Termite RNAi and Increases Fungal Efficacy.Biomolecules · 2025Article
- Multiple glutathione-S-transferases detoxify diverse glucosinolate-based defenses of Brassicales plants in a generalist lepidopteran herbivore (Spodoptera littoralis).Communications biology · 2025Article
- Plant-aphid interactions: recent trends in plant resistance to aphids.Stress biology · 2025Review
- Glucosinolate structural diversity shapes recruitment of a metabolic network of leaf-associated bacteria.Nature communications · 2024Article
- A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment.Mycobiology · 2024Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beauveria bassiana is a soil fungus that parasitizes a large number of arthropod species, including numerous crop pests, causing white muscardine disease and is therefore used as a biological insecticide. However, some insects, such as the cabbage aphid (Brevicoryne brassicae), defend themselves chemically by sequestering dietary pro-toxins (glucosinolates) from their Brassicales host plants. Glucosinolates are accumulated by cabbage aphids and activated to form toxic isothiocyanates when under attack. While isothiocyanate formation protects aphids against most attackers, B. bassiana is still able to infect the cabbage aphid under natural conditions. We therefore investigated how this fungus is able to circumvent the chemical defense system of the cabbage aphid. Here, we describe how B. bassiana infection activates the cabbage aphid defense system, but the resulting toxins are metabolized by B. bassiana via the mercapturic acid pathway, of which the first step is catalyzed by glutathione-S-transferases of low substrate specificity. This detoxification pathway enhances B. bassiana growth when isothiocyanates are present in natural concentrations, and so appears to be an important factor in fungal parasitization of these chemically defended aphids.
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