Evidence map›Paper›PMID 37479851›Full record

ArticleMolecular neurobiology2023

Disrupted in Schizophrenia 1 Reverse Ectopic Migration of Neural Precursors in Mouse Hilus After Pilocarpine-Induced Status Epilepticus.

Lu Chen, Jing Xu, Lin Zhu, Puying Xu, Lvhua Chang, Yanbing Han, Qian Wu

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lu ChenDepartment of Neurology, First Affiliated Hospital, Kunming Medical University, 295 Xi Chang Road, Kunming, Yunnan, 650032, People's Republic of China.
Jing XuDepartment of Neurology, First Affiliated Hospital, Kunming Medical University, 295 Xi Chang Road, Kunming, Yunnan, 650032, People's Republic of China.
Lin ZhuDepartment of Neurology, First Affiliated Hospital, Kunming Medical University, 295 Xi Chang Road, Kunming, Yunnan, 650032, People's Republic of China.
Puying XuDepartment of Neurology, Northeast Yunnan Hospital, Mengquan Avenue, Zhaoyang District, Zhaotong, Yunnan, 657000, People's Republic of China.
Lvhua ChangDepartment of Neurology, First Affiliated Hospital, Kunming Medical University, 295 Xi Chang Road, Kunming, Yunnan, 650032, People's Republic of China.
Yanbing Han *Department of Neurology, First Affiliated Hospital, Kunming Medical University, 295 Xi Chang Road, Kunming, Yunnan, 650032, People's Republic of China. ynhyb@163.com.
Qian Wu *Department of Neurology, First Affiliated Hospital, Kunming Medical University, 295 Xi Chang Road, Kunming, Yunnan, 650032, People's Republic of China. qianwu@ydyy.cn.ORCID http://orcid.org/0000-0002-6259-7434
Kunming Medical University · CNZhaotong University · CN

Funding

the National Natural Science Foundation of China 81601134the National Natural Science Foundation of China 82160260the National Natural Science Foundation of China 82160261the Scientific Research Fund Project of the Education Department of Yunnan Province 2022Y218the Young and Middle-aged Academic and Technical Leaders Reserve Talents Project of Yunnan Province Science and Technology Department 202205AC160019the Yunnan Health Training Project of High-Level Talents H-2018056the Yunnan Health Training Project of High-Level Talents L-2019019Yunnan Applied Basic Research Projects 202201AY070001-083
6 · The paper itself

Abstract

Neural precursors in the subgranular zone (SGZ) can be stimulated by status epilepticus (SE) and ectopically migrate to the hilus. These mislocated cells serve as "potential pacemakers" of spontaneous recurrent seizures, and targeting them could potentially reverse the seizure process. Disrupted-in-Schizophrenia 1 (DISC1) regulates hippocampal neurogenesis after seizures both in vitro and in vivo. Our previous study found that DISC1 was colocalized with neural precursors in the hilus after SE. However, its molecular mechanism and pathways contribute to the ectopic migration of neural precursors to the hilus induced by SE awaits exploration. Here, we showed that both Reelin-ApoER2/EphB2 and Reelin-Integrin β1/Integrin α5 axes may participate in the modulation of neurogenesis after SE. Especially, DISC1, as a protective role, might partly reversed the ectopic progenitor migration via EphB2 pathway. Our findings demonstrated that DISC1 played a protective role in the ectopic migration of neural precursors induced by SE insults and DISC1 could be an attractive new target for the treatment of epilepsy.

Indexed as

SchizophreniaStatus EpilepticusAnimalsMiceNeurogenesisPilocarpineSeizuresPilocarpineDISC1HilusMigrationNeural precursorsStatus epilepticus

Identifiers

PMID37479851
OpenAlexW4384943175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.