ArticleNeuroradiology2023
Prospective T1 mapping to assess gadolinium retention in brain after intrathecal gadobutrol.
Article in Neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Beyond FLAIR: PRISM (polarity-preserving real inversion solute mapping)-a new Frontier in real inversion recovery MRI for intracranial and sensory organ fluid assessment.Japanese journal of radiology · 2026Review
- Relaxivity of Gadobutrol and Gadoteric Acid in Cerebrospinal Fluid at 3T.Magnetic resonance in medicine · 2026Article
- Physical exercise as a non-pharmacological strategy to enhance glymphatic function.IBRO neuroscience reports · 2026Review
- The impact of human brain geometry on the transport of an intrathecal tracer.Fluids and barriers of the CNS · 2026Article
- Do enlarged white matter perivascular spaces reflect brain clearance dysfunction? Insights from intrathecal contrast-enhanced MRI.Neuroradiology · 2026Article
- Review
- Review
- A method for measuring first glymphatic influx of a cerebrospinal fluid tracer in the human brain.Frontiers in neuroscience · 2025Article
- Different Glymphatic Kinetics in Spontaneous Intracranial Hypotension.AJNR. American journal of neuroradiology · 2024Article
- The Cerebrovascular Side of Plasticity: Microvascular Architecture across Health and Neurodegenerative and Vascular Diseases.Brain sciences · 2024Review
- Neurosurgery and the glymphatic system.Acta neurochirurgica · 2024Review
- Glymphatic-lymphatic coupling: assessment of the evidence from magnetic resonance imaging of humans.Cellular and molecular life sciences : CMLS · 2024Review
- Mechanisms behind changes of neurodegeneration biomarkers in plasma induced by sleep deprivation.Brain communications · 2023Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeA possible pathway behind gadolinium retention in brain is leakage of contrast agents from blood to cerebrospinal fluid and entry into brain along perivascular (glymphatic) pathways. The object of this study was to assess for signs of gadolinium retention in brain 4 weeks after intrathecal contrast enhanced MRI.
methodsWe prospectively applied standardized T1 mapping of the brain before and 4 weeks after intrathecal administration of 0.5 mmol gadobutrol in patients under work-up of cerebrospinal fluid circulation disorders. Due to methodological limitations, a safety margin for percentage change in T1 time was set to 3%. Region-wise differences were assessed by pairwise comparison using t-tests and forest plots, and statistical significance was accepted at .05 level (two-tailed).
resultsIn a cohort of 76 participants (mean age 47.2 years ± 17.9 [standard deviation], 47 women), T1 relaxation times remained unchanged in cerebral cortex and basal ganglia 4 weeks after intrathecal gadobutrol. T1 was reduced from 1082 ± 46.7 ms to 1070.6 ± 36.5 ms (0.98 ±2.9%) (mean [standard deviation]) (p=0.001) in white matter, thus within the pre-defined 3% safety margin. The brain stem and cerebellum could not be assessed due to poor alignment of posterior fossa structures at scans from different time points.
conclusionGadolinium retention was not detected in the cerebral hemispheres 4 weeks after an intrathecal dose of 0.5 mmol gadobutrol, implying that presence of contrast agents in cerebrospinal fluid is of minor importance for gadolinium retention in brain.
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