ArticleAcademic radiology2024
Association of CT-Derived Skeletal Muscle and Adipose Tissue Metrics with Frailty in Older Adults.
Article in Academic radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 5 citations in OpenAlex.
- Tumor survivors' musculoskeletal health assessment: advances in imaging biomarkers for cancer treatment-related sequelae.Journal of orthopaedic surgery and research · 2026Review
- The "fat heat-up" phenotype: adipose tissue hypermetabolism on 18 F-FDG PET/CT predicts frailty in older patients with solid tumours.European journal of nuclear medicine and molecular imaging · 2026Article
- Frailty for cardiovascular risk stratification in CKM syndrome stages 0-3: a UK Biobank prospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- AI-driven CT assessment of erector spinae myosteatosis: muscle quality and its association with strength and frailty in older surgical patients.Frontiers in medicine · 2026Article
- Intramuscular Fat as a Biomarker of Muscle Health: Strengths, Limitations and Open Challenges.Journal of cachexia, sarcopenia and muscle · 2026Review
- Opportunistic Assessment for Parathyroid Adenoma on CT: A Retrospective Cohort Study Evaluating Primary Hyperparathyroidism-Associated Morbidity Over 10 Years of Follow-Up.AJR. American journal of roentgenology · 2025Article
- Advancements in sarcopenia diagnosis: from imaging techniques to non-radiation assessments.Frontiers in medical technology · 2024Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
RATIONALE AND
objectivesTools are needed for frailty screening of older adults. Opportunistic analysis of body composition could play a role. We aim to determine whether computed tomography (CT)-derived measurements of muscle and adipose tissue are associated with frailty. MATERIALS AND
methodsOutpatients aged ≥ 55 years consecutively imaged with contrast-enhanced abdominopelvic CT over a 3-month interval were included. Frailty was determined from the electronic health record using a previously validated electronic frailty index (eFI). CT images at the level of the L3 vertebra were automatically segmented to derive muscle metrics (skeletal muscle area [SMA], skeletal muscle density [SMD], intermuscular adipose tissue [IMAT]) and adipose tissue metrics (visceral adipose tissue [VAT], subcutaneous adipose tissue [SAT]). Distributions of demographic and CT-derived variables were compared between sexes. Sex-specific associations of muscle and adipose tissue metrics with eFI were characterized by linear regressions adjusted for age, race, ethnicity, duration between imaging and eFI measurements, and imaging parameters.
resultsThe cohort comprised 886 patients (449 women, 437 men, mean age 67.9 years), of whom 382 (43%) met the criteria for pre-frailty (ie, 0.10 < eFI ≤ 0.21) and 138 (16%) for frailty (eFI > 0.21). In men, 1 standard deviation changes in SMD (β = -0.01, 95% confidence interval [CI], -0.02 to -0.001, P = .02) and VAT area (β = 0.008, 95% CI, 0.0005-0.02, P = .04), but not SMA, IMAT, or SAT, were associated with higher frailty. In women, none of the CT-derived muscle or adipose tissue metrics were associated with frailty.
conclusionWe observed a positive association between frailty and CT-derived biomarkers of myosteatosis and visceral adiposity in a sex-dependent manner.
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