ReviewSchizophrenia bulletin2023
Resolving the Delusion Paradox.
Review in Schizophrenia bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Apical integration theory provides a neural basis for understanding disorganization and consciousness in the schizophrenias.Current research in neurobiology · 2026Article
- The role of attention in perceptual biases in patients with schizophrenia spectrum disorder and healthy controls.European archives of psychiatry and clinical neuroscience · 2026Article
- Social expectations in early-stage psychosis: Less stereotypical facial expression predictions.Schizophrenia research. Cognition · 2026Article
- Preserved contextual modulation of eye movements in psychosis prone individuals.Journal of vision · 2026Article
- A review and integration of models on delusion maintenance.Psychological medicine · 2026Review
- From neuroinflammation to neural inference: computational psychiatry meets precision medicine.Schizophrenia (Heidelberg, Germany) · 2026Review
- Helping Patients With Persecutory Delusions Find Safety.Schizophrenia bulletin · 2026Article
- Review
- Lifetime MDMA use and associations with meaning in life in the context of childhood trauma.Scientific reports · 2026Article
- Neurobiological illness models of schizophrenia and stigma reduction: has that ship sailed?Schizophrenia (Heidelberg, Germany) · 2025Review
- Altered processing of self-produced sensations in psychosis at cortical and spinal levels.Molecular psychiatry · 2025Article
- Reduced weighting of short-term perceptual priors during auditory perceptual decision-making in psychosis-prone individuals.BMC biology · 2025Article
- Placebo and nocebo phenomena in schizophrenia spectrum disorders: a narrative review on current knowledge and potential future directions.Psychological medicine · 2025Review
- Developing algorithmic psychiatry via multi-level spanning computational models.Cell reports. Medicine · 2025Review
- A Computational Account of the Development and Evolution of Psychotic Symptoms.Biological psychiatry · 2025Review
- Anterior insular activity signals perceptual conflicts induced by temporal and spatial context.Neuroscience of consciousness · 2025Article
- Individual differences in belief updating and phasic arousal are related to psychosis proneness.Communications psychology · 2024Article
- Distinct alterations in probabilistic reversal learning across at-risk mental state, first episode psychosis and persistent schizophrenia.Scientific reports · 2024Article
- Associations of conservatism and jumping to conclusions biases with aberrant salience and default mode network.Psychiatry and clinical neurosciences · 2024Article
- A new predictive coding model for a more comprehensive account of delusions.The lancet. Psychiatry · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
background and hypothesisThe neurocomputational framework of predictive processing (PP) provides a promising approach to explaining delusions, a key symptom of psychotic disorders. According to PP, the brain makes inferences about the world by weighing prior beliefs against the available sensory data. Mismatches between prior beliefs and sensory data result in prediction errors that may update the brain's model of the world. Psychosis has been associated with reduced weighting of priors relative to the sensory data. However, delusional beliefs are highly resistant to change, suggesting increased rather than decreased weighting of priors. We propose that this "delusion paradox" can be resolved within a hierarchical PP model: Reduced weighting of prior beliefs at low hierarchical levels may be compensated by an increased influence of higher-order beliefs represented at high hierarchical levels, including delusional beliefs. This may sculpt perceptual processing into conformity with delusions and foster their resistance to contradictory evidence. STUDY
designWe review several lines of experimental evidence on low- and high-level processes, and their neurocognitive underpinnings in delusion-related phenotypes and link them to predicted processing. STUDY
resultsThe reviewed evidence supports the notion of decreased weighting of low-level priors and increased weighting of high-level priors, in both delusional and delusion-prone individuals. Moreover, we highlight the role of prefrontal cortex as a neural basis for the increased weighting of high-level prior beliefs and discuss possible clinical implications of the proposed hierarchical predictive-processing model.
conclusionsOur review suggests the delusion paradox can be resolved within a hierarchical PP model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.