ArticleImmunity2023
Obesity-induced dysregulation of skin-resident PPARγ
Open access · bronzeAbstract read
In one paragraph
Article in Immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
15.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Transcriptomic meta-analysis characterizes molecular commonalities between psoriasis and obesity.Genes and immunity · 2024Pooled it
- Targeting Cannabinoid 1 Receptor in Macrophages Alleviates Psoriatic Skin Inflammation Through the AUF1-NLRP3 Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Obesity Promotes Lung Carcinogenesis Through Airway Immune Dysfunction.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026Article
- Rewiring the psoriasis-metabolism axis: therapeutic potential of saroglitazar beyond PPAR modulation.Inflammopharmacology · 2026Review
- Palmitic acid coordinates impaired visceral adipose ICOShi Treg-mediated immunosuppression and systemic metabolic disturbance during obesity.The Journal of clinical investigation · 2026Article
- Phytochemicals and Irisin as Multi-Target Regulators of Adipose Tissue Browning and Metabolic Reprogramming: Synergies with GLP-1 Pathways.Antioxidants (Basel, Switzerland) · 2026Review
- Regulatory T cells in the skin: Origin, function, and plasticity.JID innovations : skin science from molecules to population health · 2026Review
- Clinical Outcomes After Week-12 Response-Guided Secukinumab Discontinuation in Psoriasis: A Prospective Real-World Cohort Study.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026Article
- GLP-1 receptor agonists in osteoarthritis and psoriatic disease: the missing link between obesity and inflammation?Rheumatology international · 2026Review
- Gut microbiota shapes the effects of saturated and polyunsaturated fatty acids on skin and hair follicle homeostasis.The Journal of investigative dermatology · 2026Article
- Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2-deficient environments.The Journal of experimental medicine · 2026Article
- Macrophage INSIG1 deficiency drives psoriasiform dermatitis via the SREBP2-STAT1 axis.Nature communications · 2026Article
- Tryptophan metabolism in psoriasis and its complications: Future opportunities.Journal of advanced research · 2026Review
- Metabolic pattern changes of macrophages during cancer development and progression.Journal of translational medicine · 2026Review
- Abundances but not concentrations of circulating unsaturated fatty acids are associated with incident psoriatic diseases: Evidence from cohort and Mendelian randomization studies.JID innovations : skin science from molecules to population health · 2026Article
- Epithelial-dermal inflammasome crosstalk in cutaneous squamous cell carcinoma.Molecular biology of the cell · 2026Article
- Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity.Communications medicine · 2026Article
- Inflammatory immune mechanisms underlying the comorbidity of psoriasis and atherosclerosis: clinical implications.Frontiers in immunology · 2026Review
- PPARγ: a key orchestrator of epidermal barrier, immune responses, and lipid metabolism in atopic dermatitis pathogenesis and therapy.Frontiers in allergy · 2026Review
- Fatty acid-related immune network in psoriasis: metabolic regulation of innate and adaptive immunity.Frontiers in pharmacology · 2026Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Pulavendran SivasamiDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Cody ElkinsDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Pamela P Diaz-SaldanaDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Kyndal GossAflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Amy PengDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Michael HamerskyDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Jennifer BaeDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Miaoer XuDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Brian P PollackAtlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA; Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.
Edwin M HorwitzAflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Christopher D ScharerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Lindsey SeldinDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA; Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA; Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.
Chaoran LiDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: chaoran.li@emory.edu.
Emory University · US
Funding
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1MWinship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5MAtlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8MCytokine and Metabolic Regulation of Adipose-tissue TregsR01DK128061 · NIDDK · EMORY UNIVERSITY · PI LI, CHAORAN · 2021 to 2025
$2.3MThe Role of Dermal Fibroblasts in Skin CancerIK2BX005370 · VA · VETERANS HEALTH ADMINISTRATION · PI SELDIN, LINDSEY NICOLE · 2022 to 2025
–BLRD VA IK2 BX005370NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR002378NCI NIH HHS P30 CA138292NIDDK NIH HHS R01 DK128061
Abstract
Obesity is a major risk factor for psoriasis, but how obesity disrupts the regulatory mechanisms that keep skin inflammation in check is unclear. Here, we found that skin was enriched with a unique population of CD4
Indexed as
PsoriasisT-Lymphocytes, RegulatoryAnimalsInflammationInterleukin-17MiceObesityPPAR gammaSkinInterleukin-17PPAR gammafree fatty acidhigh-fat dietIL-17AimmunometabolismobesityPPARγpsoriasisskinTregγδ T cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.