Evidence map›Paper›PMID 37478090›Full record

ArticlePloS one2023

Effects of Rhazya Stricta plant organic extracts on human induced pluripotent stem cells derived neural stem cells.

Abdullah Othman Alawad, Faisal Sultan Alagrafi, Ahmed Jaman Alfahad, Hala Abdulrahman Alamari, Fatimah Othman Alghamdi, Hussam Mokhtar Fallatah, Alhassan Hamood Aodah, Sultan Suleiman Alyousef, Muhammed Adnan Bakhrebah, Ibrahim Oqla Alanazi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Abdullah Othman AlawadAging Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.ORCID 0000-0003-1924-5879
Faisal Sultan AlagrafiAging Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Ahmed Jaman AlfahadBioengineering Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Hala Abdulrahman AlamariBioengineering Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Fatimah Othman AlghamdiBioengineering Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Hussam Mokhtar FallatahWaste Management and Recycling Institute, Sustainability and Environment Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Alhassan Hamood AodahAdvanced Diagnostics and Therapeutics Technologies Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Sultan Suleiman AlyousefAdvanced Diagnostics and Therapeutics Technologies Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Muhammed Adnan BakhrebahAdvanced Diagnostics and Therapeutics Technologies Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Ibrahim Oqla AlanaziAging Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.ORCID 0000-0002-8479-7875
Mohannad Mokhtar FallatahAdvanced Diagnostics and Therapeutics Technologies Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.ORCID 0000-0002-4483-7131
King Abdulaziz City for Science and Technology · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rhazya Stricta (R. stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R. stricta extracts contain alkaloids, tannins, and flavonoids that possess antimicrobial, anticancer, antihypertensive, and antioxidant activities. In this study, we examined the effects of organic extracts from different parts of R. stricta plant on human pluripotent stem cells (hiPSCs)-derived neural stem cells (NSCs) for medical purposes. NSCs were incubated with different concentrations of organic extracts from the leaves, stem, and fruits, and we assessed the growth and viability of the cells by using MTS assay and the chemical composition of the potential plant extract by using gas chromatography-mass spectrometry (GC/MS). Our results revealed that the methanolic extract from the stem increased NSCs growth significantly, particularly at a concentration of 25 μg/ml. GC/MS analysis was utilized to identify the potential compounds of the methanolic extract. In conclusion, our results demonstrated for the first time that methanolic stem extract of R. stricta contains compounds that can positively impact NSCs growth. These compounds can be further investigated to determine the potential bioactive compounds that can be used for research and medical purposes.

Indexed as

AlkaloidsApocynaceaeInduced Pluripotent Stem CellsAntioxidantsHumansPlant ExtractsPlant LeavesAlkaloidsAntioxidantsPlant Extracts

Identifiers

PMID37478090
PMCPMC10361509
OpenAlexW4385064454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.