Evidence map›Paper›PMID 37477839›Full record

SynthesisNeuropsychology review2024

The Associations Between Neuropsychiatric Symptoms and Cognition in People with Dementia: A Systematic Review and Meta-Analysis.

Julieta Sabates, Wei-Hsuan Chiu, Samantha Loi, Amit Lampit, Hanna M Gavelin, Terence Chong, Nathalie Launder, Anita M Y Goh, Amy Brodtmann, Nicola Lautenschlager and 1 more

Open access · hybridAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuropsychology review, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Characterization of neuropsychiatric symptoms in patients with early-stage Alzheimer's disease in a specialized outpatient clinic.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Observational
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Association of RDoC dimensions withAlzheimer's & dementia (Amsterdam, Netherlands)
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Julieta SabatesThe University of Melbourne, 151 Barry Street, Carlton, VIC, Australia. Julieta.sabates@unimelb.edu.au.ORCID http://orcid.org/0000-0003-1462-6381
Wei-Hsuan ChiuThe University of Melbourne, 151 Barry Street, Carlton, VIC, Australia.
Samantha LoiThe University of Melbourne, 151 Barry Street, Carlton, VIC, Australia.
Amit LampitThe University of Melbourne, 151 Barry Street, Carlton, VIC, Australia.
Hanna M GavelinThe University of Melbourne, 151 Barry Street, Carlton, VIC, Australia.
Terence ChongThe University of Melbourne, 151 Barry Street, Carlton, VIC, Australia.
Nathalie LaunderThe University of Melbourne, 151 Barry Street, Carlton, VIC, Australia.
Anita M Y GohNational Ageing Research Institute &, The University of Melbourne, Parkville, Australia.
Amy BrodtmannCentral Clinical School, Cognitive Health Initiative, Monash University, Melbourne, Australia.
Nicola LautenschlagerThe University of Melbourne, 151 Barry Street, Carlton, VIC, Australia.
Alex Bahar-FuchsThe University of Melbourne, 151 Barry Street, Carlton, VIC, Australia.
The University of Melbourne · AUThe Royal Melbourne Hospital · AUDeakin University · AUMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most people with dementia experience neuropsychiatric symptoms (NPS), including anxiety, depression or disinhibition. There is growing interest in the relationship between NPS and cognitive impairment, but data is still limited. This study aimed to investigate the specific associations between NPS and cognition in people with dementia. MEDLINE, EMBASE and PsycINFO were searched for published, peer-reviewed studies of associations between at least one NPS and one cognitive ability in people with dementia. The quality of the studies was assessed with the NIH National Heart, Lung and Blood Institute's quality assessment tools. A meta-analysis was conducted using Robumeta package for R. Ninety studies were included. We found significant associations between NPS, global cognition and cognitive domains, e.g. apathy was associated with global cognitive and memory impairment; dysphoria was associated with worse attention; delusions with executive dysfunction. Increased NPS in people with dementia are associated with worse cognitive performance. There were few studies looking at associations between some neuropsychiatric clusters and cognitive abilities, and there was little research on causal relationships. Our review was limited by the inclusion of studies that reported associations in specific formats, and most included people with a diagnosis of Alzheimer's disease (AD). However, given the large number of studies, this is unlikely to have biased results. More research is needed that includes diverse people with different dementia syndromes. Registration: PROSPERO 2020 CRD42020165565.

Indexed as

Cognitive DysfunctionDementiaAlzheimer DiseaseCognitionHumansCognitionDementiaNeuropsychiatric symptoms

Identifiers

PMID37477839
PMCPMC11166771
OpenAlexW4384924562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.