Evidence map›Paper›PMID 37477671›Full record

ReviewRadiologie (Heidelberg, Germany)2023

[Neuropathology of pediatric brain tumors : Implications of the 5th edition of the WHO classification of central nervous system tumors].

Bernardo Reyes Medina, Arne Wrede, Walter J Schulz-Schaeffer

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Radiologie (Heidelberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 68% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Bernardo Reyes MedinaInstitut für Neuropathologie, Medizinische Fakultät, Universität des Saarlandes und Universitätsklinikum des Saarlandes, Kirrberger Str. 100, Gebäude 90.3, 66421, Homburg, Deutschland.
Arne WredeInstitut für Neuropathologie, Medizinische Fakultät, Universität des Saarlandes und Universitätsklinikum des Saarlandes, Kirrberger Str. 100, Gebäude 90.3, 66421, Homburg, Deutschland.
Walter J Schulz-SchaefferInstitut für Neuropathologie, Medizinische Fakultät, Universität des Saarlandes und Universitätsklinikum des Saarlandes, Kirrberger Str. 100, Gebäude 90.3, 66421, Homburg, Deutschland. walter.schulz-schaeffer@uks.eu.
Universitätsklinikum des Saarlandes · DESaarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlready with the update of the 4th edition of the World Health Organization (WHO) classification of tumors of the central nervous system, it was pointed out that pediatric diffuse glioma do not follow the same molecular mechanisms used to characterize adult diffuse glioma.

objectivesWhat changes result from the update of the classification of tumors of the central nervous system?

methodsWith the 5th edition of the WHO classification of tumors of the central nervous system, a second level of information containing molecular changes besides the histological characterization and grading of tumors was established.

resultsA new classification of diffuse pediatric brain tumors based on molecular tumor pathways was established. The most important tumor pathways, considered for the new classification, were the activation of receptor tyrosine kinases and histone H3 alterations that cause epigenetic changes.

conclusionsIncreasingly better understanding of mechanisms in the development of pediatric brain tumors gives hope for more specific therapeutic approaches.

Indexed as

Brain NeoplasmsCentral Nervous System NeoplasmsGliomaAdultCentral Nervous SystemChildHumansWorld Health OrganizationDiffuse pediatric gliomaModular diagnosisMolecular pathologyTumors of the central nervous systemWHO classification

Identifiers

PMID37477671
OpenAlexW4384925753

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.