ArticleBlood advances2023
EASIX-1year and late mortality after allogeneic stem cell transplantation.
Article in Blood advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 29 citations in OpenAlex.
- Prognostic impact of P-m-EASIX at neutrophil engraftment after allogeneic hematopoietic stem cell transplantation.International journal of hematology · 2026Article
- Early EASIX and Short-Term Mortality After Acute Myocardial Infarction: A Dual-Cohort Prognostic Study.Journal of clinical medicine · 2026Article
- Evaluation of a novel eHealth-facilitated, post HCT-integrated care model on implementation and rehospitalization: results from the Swiss SMILe hybrid-RCT.Bone marrow transplantation · 2026Article
- Prognostic value of endothelial activation and stress index (EASIX) on short-term and long-term outcomes in type B aortic dissection after thoracic endovascular repair: An observational study.JTCVS structural and endovascular · 2026Article
- Endothelial activation and stress index is independently associated with arteriogenic erectile dysfunction: a cross-sectional study.Sexual medicine · 2026Article
- Independent and Incremental Prognostic Value of the Endothelial Activation and Stress Index Beyond the GRACE Score for Predicting 1-Year Mortality in Patients with Non-ST-Segment Elevation Myocardial Infarction.Medicina (Kaunas, Lithuania) · 2026Article
- Prognostic significance of the endothelial activation and stress index in acute respiratory distress syndrome: a retrospective cohort study.Scientific reports · 2026Article
- Deciphering elevated risk of life-threatening hemorrhage and early death in acute myeloid leukemia with APL-like phenotype: independent role of endothelial injury and implications of EASIX-based risk stratification in a multicenter study.Journal of translational medicine · 2026Article
- Article
- Association between Endothelial Activation and Stress Index and mortality in patients with coronary heart disease at intensive care unit: a retrospective cohort study.Journal of thoracic disease · 2026Article
- Association between the endothelial activation and stress index and 30-day in-hospital mortality rate in patients with traumatic lung injury: a retrospective analysis based on the MIMIC-IV database.Journal of thoracic disease · 2026Article
- Association of endothelial activation and stress index with all-cause and cardiovascular mortality in patients with diabetic kidney disease: a population-based prospective study.Diabetology & metabolic syndrome · 2026Article
- Regulating effect of genistein on the association of endothelial activation and stress index with atherosclerotic cardiovascular disease risk: a cross-sectional study of the NHANES database.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Associations of the Endothelial Activation and Stress Index with breast cancer prevalence and mortality based on NHANES 2001 to 2018.Medicine · 2026Article
- Article
- Association between the Endothelial Activation and Stress Index and all-cause mortality in patients with chronic obstructive pulmonary disease.Frontiers in medicine · 2026Article
- Association of EASIX Score with Non-relapse Mortality and Overall Survival in Pediatric Acute Leukemia Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.Stem cell reviews and reports · 2026Article
- Relationship between Endothelial Activation and Stress Index and Coronary Artery Ectasia.Arquivos brasileiros de cardiologia · 2026Article
- Article
- EASIX as a predictor of 3-year mortality in aortic stenosis patients undergoing TAVR.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
Patients with hematological malignancies who survive the first year after allogeneic stem cell transplantation (allo-SCT) without relapse have a substantial risk of nonrelapse mortality (NRM) and missing predictive markers. The Endothelial Activation and Stress Index (EASIX) predicts endothelial complications and NRM early after allo-SCT. We hypothesized that EASIX assessed 1 year after allo-SCT in survivors who were disease free may predict late NRM. Survivors who were relapse-free at 1 year after allo-SCT were retrospectively studied in 2 independent cohorts (training cohort, n = 610; merged validation cohort, n = 852). EASIX determined 1 year after allo-SCT correlated with the overall survival (OS), NRM, and relapse. Serum endothelial and inflammatory markers were measured in the training cohort and correlated with EASIX-1year, which predicted OS and NRM but not relapse risk in both the training and validation cohorts in univariable and multivariable Cox regression analyses. Brier score and c-index analyses validated the univariable EASIX effects. There was no significant interaction between EASIX-1year and incidence of chronic graft-versus-host disease (GVHD) on OS. EASIX-1year predicted the outcome irrespective of preexisting comorbidities. Principal causes of NRM in both training and validation cohorts were infections with and without GVHD as well as cardiovascular complications. EASIX-1year correlated with sCD141 and interleukin-18 but not with C-reactive protein, suppressor of tumorigenicity-2, angiopoietin-2, CXCL9, or CXCL8. To our knowledge, EASIX-1year is the first validated predictor of late overall and NRM. Patients who are high risk as defined by EASIX-1year might be considered for intensified surveillance and prophylactic measures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.