Evidence map›Paper›PMID 37476995›Full record

ArticleAnnals of surgery2023

Severity of Prior Coronavirus Disease 2019 is Associated With Postoperative Outcomes After Major Inpatient Surgery.

Nathaniel B Verhagen, Gopika SenthilKumar, Taylor Jaraczewski, Nicolas K Koerber, Jennifer R Merrill, Madelyn A Flitcroft, Aniko Szabo, Anjishnu Banerjee, Xin Yang, Bradley W Taylor and 8 more

Open access · greenAbstract read
In one paragraph

Article in Annals of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Impact of COVID-19 on Opioid Prescribing, Consumption, Pain, and Outcomes after Surgery.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025
    Article
  7. Article
  8. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Nathaniel B VerhagenDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Gopika SenthilKumarDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Taylor JaraczewskiDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Nicolas K KoerberDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Jennifer R MerrillDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Madelyn A FlitcroftDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Aniko SzaboDepartment of Biostatistics, Medical College of Wisconsin, Milwaukee, WI.
Anjishnu BanerjeeDepartment of Biostatistics, Medical College of Wisconsin, Milwaukee, WI.
Xin YangClinical and Translational Science Institute of Southeast Wisconsin, Medical College of Wisconsin, Milwaukee, WI.
Bradley W TaylorClinical and Translational Science Institute of Southeast Wisconsin, Medical College of Wisconsin, Milwaukee, WI.
Carlos E Figueroa CastroDepartment of Medicine, Division of Infectious Diseases, Medical College of Wisconsin, Milwaukee, WI.
Tina W F YenDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Callisia N ClarkeDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Kathryn LauerDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI.
Kurt J PfeiferDepartment of Medicine, Section of Perioperative and Consultative Medicine, Medical College of Wisconsin, Milwaukee, WI.
Jon C GouldDepartment of Surgery, Division of Minimally Invasive and GI Surgery, Medical College of Wisconsin, Milwaukee, WI.
Anai N KothariDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
N3C Consortium
Medical College of Wisconsin · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
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6 · The paper itself

Abstract

objectiveTo determine how the severity of prior history (Hx) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection influences postoperative outcomes after major elective inpatient surgery.

backgroundSurgical guidelines instituted early in the coronavirus disease 2019 (COVID-19) pandemic recommended a delay in surgery of up to 8 weeks after an acute SARS-CoV-2 infection. This was based on the observation of elevated surgical risk after recovery from COVID-19 early in the pandemic. As the pandemic shifts to an endemic phase, it is unclear whether this association remains, especially for those recovering from asymptomatic or mildly symptomatic COVID-19.

methodsUtilizing the National COVID Cohort Collaborative, we assessed postoperative outcomes for adults with and without a Hx of COVID-19 who underwent major elective inpatient surgery between January 2020 and February 2023. COVID-19 severity and time from infection to surgery were each used as independent variables in multivariable logistic regression models.

resultsThis study included 387,030 patients, of whom 37,354 (9.7%) were diagnosed with preoperative COVID-19. Hx of COVID-19 was found to be an independent risk factor for adverse postoperative outcomes even after a 12-week delay for patients with moderate and severe SARS-CoV-2 infection. Patients with mild COVID-19 did not have an increased risk of adverse postoperative outcomes at any time point. Vaccination decreased the odds of respiratory failure.

conclusionsImpact of COVID-19 on postoperative outcomes is dependent on the severity of illness, with only moderate and severe disease leading to a higher risk of adverse outcomes. Existing perioperative policies should be updated to include consideration of COVID-19 disease severity and vaccination status.

Indexed as

COVID-19AdultElective Surgical ProceduresHumansInpatientsRisk FactorsSARS-CoV-2

Identifiers

PMID37476995
PMCPMC10659141
OpenAlexW4384922313

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.