ArticleCirculation. Heart failure2023
Prognostic Value of the Anatomic-Physiologic Classification in Adults With Congenital Heart Disease.
Article in Circulation. Heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Prognostic value of serial NT-proBNP assay in adults with congenital heart disease and biventricular physiology.International journal of cardiology. Congenital heart disease · 2026Article
- Prognostic Implication of Heart Failure With Reduced and Midrange Ejection Fraction in Adults With Congenital Heart Disease.CJC pediatric and congenital heart disease · 2026Article
- Validation of NT-proBNP cutoff points for heart failure diagnosis in adults with CHD in the outpatient clinic and emergency department.International journal of cardiology. Congenital heart disease · 2026Article
- Prognostic implications of heart failure rehospitalization in adults with CHD & clinical benefits of medical therapy.International journal of cardiology. Congenital heart disease · 2025Article
- Transcatheter Valve Replacement in Adults With Congenital Heart Disease-The Mayo Clinic Experience.Circulation. Cardiovascular interventions · 2025Article
- Clinical outcomes after implantation of bioprosthetic valves in adults with congenital heart disease.International journal of cardiology. Congenital heart disease · 2025Article
- Mechanical valve replacement in adults with Fontan physiology is an effective palliation in selected patients.International journal of cardiology. Congenital heart disease · 2025Article
- Role of strain imaging for risk stratification in Fontan patients with normal ventricular ejection fraction.European heart journal. Cardiovascular Imaging · 2025Article
- Progressive LV Dysfunction and Adverse Outcomes After Aortic Valve Replacement With Bioprosthetic Valves in Young Patients.Circulation. Cardiovascular imaging · 2025Article
- Incidence, Correlates, and Prognostic Implications of New-Onset Atrial Fibrillation in Adults With Repaired Coarctation of Aorta.CJC pediatric and congenital heart disease · 2024Article
- Influenza Vaccination in Adult Patients With Congenital Heart Disease.JACC. Advances · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe prognostic role of the congenital heart disease (CHD) anatomic/physiologic classification has not been systematically studied. The purpose of this study was to determine whether CHD physiologic stage provided improvement in prognostic power (to predict all-cause mortality) beyond conventional clinical risk models.
methodsRetrospective study of adults with CHD at the Mayo Clinic (2003-2019). The CHD physiologic stage was assessed at baseline and 36 (24-48) months, and patients were classified into stages A to D at these time points. Clinical stability (remaining in the same stage), clinical improvement (moving to less advanced stage), and clinical deterioration (moving to more advanced stage) were determined at 36 months. We defined conventional clinical risk indices as age/sex, functional class, comorbidities, cardiac procedures, hepatorenal dysfunction, and ventricular/valvular dysfunction.
resultsOf 5321 patients, 1649 (31%), 1968 (37%), 1224 (23%), and 480 (9%) were in stages A, B, C, and D at baseline. Of 5321 patients, 4588 (86%) also had assessments at 36 months, and of these patients, 3347 (73%), 386 (8%), and 855 (19%) had clinical stability, deterioration, and improvement, respectively. Patients with clinical improvement were more likely to have undergone cardiac procedures between both assessments. Both baseline CHD physiologic stage (hazard ratio, 1.13 [95% CI, 1.09-1.17];
conclusionsThe CHD physiologic stage can potentially be used for risk stratification, as well as to monitor disease progression and response to therapy.
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