Evidence map›Paper›PMID 37476942›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2023

Lipid nanoparticle delivery of siRNA targeting

Shuang Wu, Qiubing Chen, Yalan Wang, Hao Yin, Yuan Wei

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shuang WuSchool of Pharmacy, Jiangsu University, Zhenjiang 212013, Jiangsu Province, China. wushuang873@163.com.
Qiubing ChenDepartment of Urology, Frontier Science Centre for Immunology and Metabolism, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Yalan WangSchool of Pharmacy, Jiangsu University, Zhenjiang 212013, Jiangsu Province, China.
Hao YinDepartment of Urology, Frontier Science Centre for Immunology and Metabolism, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Yuan WeiSchool of Pharmacy, Jiangsu University, Zhenjiang 212013, Jiangsu Province, China. ywei@ujs.edu.cn.
Wuhan University · CNJiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the effect and mechanism of lipid nanoparticle (LNP) delivery of small interfering RNA (siRNA) targeting

methodssiRNA targeting

resultsCompared with the model control group, the levels of liver index, serum ALT, AST activities, malondialdehyde, reactive oxygen species, triacylglycerol, total cholesterol contents in liver tissue decreased, but the SOD activity as well as glutathione increased in the si-Cyp2e1 LNP group (all

conclusionsThe si-Cyp2e1 LNP may attenuate subacute alcoholic liver injury in mice mainly by reducing reactive oxygen levels, increasing antioxidant activity, blocking oxidative stress pathways and reducing ethanol-induced steatosis and inflammation.

Indexed as

EthanolLiverAnimalsAntioxidantsCholesterolCytochrome P-450 CYP2E1FemaleGlutathioneInflammationLipidsLiposomesMalondialdehydeMiceMice, Inbred C57BLNanoparticlesOxidative StressAntioxidantsCholesterolCytochrome P-450 CYP2E1EthanolGlutathioneLipid NanoparticlesLipidsLiposomesMalondialdehydeReactive Oxygen SpeciesRNA, Small InterferingSuperoxide DismutaseTriglyceridesInflammationLipid metabolic synthesisLipid nanoparticlesMiceOxidative stressSmall interfering RNASubacute alcoholic liver injury

Identifiers

PMID37476942
PMCPMC10409911
OpenAlexW4379525702

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.