SynthesisPediatrics2023
A Systematic Review of Persistent Clinical Features After SARS-CoV-2 in the Pediatric Population.
Synthesis in Pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Pooled it
- Pediatric post COVID-19 condition: an umbrella review of the most common symptoms and associated factors.European journal of public health · 2024Pooled it
- Pooled it
- The Burden of Long-COVID-19 Among Pediatric Subjects: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Risk factors for severe post-COVID condition in children, adolescents, and young adults.European journal of pediatrics · 2026Observational
- Interdisciplinary Pediatric Long-COVID Care: A Descriptive Study of Interventions and Health-Related Quality of Life.Open forum infectious diseases · 2026Article
- Longitudinal functional lung imaging in children with Post-COVID-19 syndrome.Molecular and cellular pediatrics · 2026Article
- Persistent physical and mental health effects of COVID-19 hospitalization.Frontiers in pediatrics · 2026Article
- Children and adolescents: Respiratory infection and long-term effects longitudinal study (CARE Study): Study protocol.PloS one · 2026Article
- Research priorities on physical-mental comorbidity in children and adolescents: an international consensus.EClinicalMedicine · 2025Review
- Long COVID syndrome in children: neutrophilic granulocyte dysfunction and its correlation with disease severity.Pediatric research · 2025Article
- Editorial: COVID-19 - lessons learned in pediatrics.Frontiers in pediatrics · 2025Article
- Exploring long COVID in pediatric patients: clinical insights from a long COVID clinic.Frontiers in pediatrics · 2025Article
- A 24-month National Cohort Study examining long-term effects of COVID-19 in children and young people.Communications medicine · 2024Article
- Body Mass Index and Postacute Sequelae of SARS-CoV-2 Infection in Children and Young Adults.JAMA network open · 2024Article
- Clinical Features and Vaccination Effects among Children with Post-Acute Sequelae of COVID-19 in Taiwan.Vaccines · 2024Article
- Clinical-based phenotypes in children with pediatric post-COVID-19 condition.World journal of pediatrics : WJP · 2024Article
- "Clinical child psychology and psychiatry · 2024Article
- Challenges and opportunities in long COVID research.Immunity · 2024Article
- Symptoms and Conditions in Children and Adults up to 90 Days after SARS-CoV-2 Infection: A Retrospective Observational Study Utilizing the Common Data Model.Journal of clinical medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextLong-term health effects after coronavirus disease 2019 (COVID-19) have been increasingly reported but their prevalence and significance in the pediatric population remains uncertain.
objectiveTo present the prevalence and characteristics of the long-term clinical features of COVID-19 (long COVID) in the global pediatric population. DATA SOURCES: PubMed, Embase, Web of Science, Cochrane Library, WHO COVID-19 database, google scholar, medRxiv, bioRxiv, and multiple national public health databases. STUDY SELECTION: Published articles and preprints from December, 2019 to December, 2022 investigating the epidemiology and characteristics of persistent clinical features at least 3 months after COVID-19 in children and adolescents (0-19 years old) were included. DATA EXTRACTION: Study characteristics and detailed description of long COVID were extracted into a predefined form.
resultsTwenty seven cohorts and 4 cross-sectional studies met the inclusion criteria and involved over 15 000 pediatric participants. A total of more than 20 persistent symptoms and clinical features were reported among children and adolescents. 16.2% (95% confidence interval 8.5% to 28.6%) of the pediatric participants experienced 1 or more persistent symptom(s) at least 3 months post COVID-19. Female gender might be associated with developing certain long COVID symptoms. LIMITATIONS: Included studies presented with great heterogeneity because of significant variations in the definition of "long COVID," follow up duration, and method. There could be nonresponse and other potential bias.
conclusionsPersistent clinical features beyond 3 months among children and adolescents with proven COVID-19 are common and the symptom spectrum is wide. High-quality, prospective studies with proper controls are necessary in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.