ArticleChemical science2023
A Pd-catalyzed highly selective three-component protocol for trisubstituted allenes.
Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Alcohol-Directed Carboamination of Conjugated Enynes.Angewandte Chemie (International ed. in English) · 2026Article
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3 authors.
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Abstract
Herein we report the first example of a Pd-catalyzed highly selective three-component reaction of alkynyl-1,4-diol dicarbonates, organoboronic acids, and malonate anions for the efficient synthesis of trisubstituted 2,3-allenyl malonates not readily available by the known protocols. The reaction demonstrates an excellent regio- and chemo-selectivity for both the oxidative addition referring to the two C-O bonds and the subsequent coupling with the nucleophile with a remarkable functional group compatibility. A series of control experiments confirm a unique mechanism involving β-O elimination forming alka-1,2,3-triene and the subsequent insertion of its terminal C[double bond, length as m-dash]C bond into the Ar-Pd bond.
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