Evidence map›Paper›PMID 37475963›Full record

ArticleFrontiers in cellular and infection microbiology2023

Infiltrated IL-17A-producing gamma delta T cells play a protective role in sepsis-induced liver injury and are regulated by CCR6 and gut commensal microbes.

Jian Wan, Qian Zhang, Yilong Hao, Zhang Tao, Wei Song, Song Chen, Long Qin, Weidong Song, Yi Shan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jian WanDepartment of Emergency and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Qian ZhangDepartment of Emergency and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Yilong HaoDepartment of Emergency and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Zhang TaoDepartment of Emergency and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Wei SongDepartment of Emergency and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Song ChenDepartment of Emergency and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Long QinDepartment of Emergency and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Weidong SongDepartment of Emergency and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Yi ShanDepartment of Emergency and Critical Care Medicine, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Pudong New Area People's Hospital · CNShanghai Changzheng Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Sepsis is a common but serious disease in intensive care units, which may induce multiple organ dysfunctions such as liver injury. Previous studies have demonstrated that gamma delta (γδ) T cells play a protective role in sepsis. However, the function and mechanism of γδ T cells in sepsis-induced liver injury have not been fully elucidated. IL-17A-producing γδ T cells are a newly identified cell subtype. Methods: We utilized IL-17A-deficient mice to investigate the role of IL-17A-producing γδ T cells in sepsis using the cecum ligation and puncture (CLP) model. Results: Our findings suggested that these cells were the major source of IL-17A and protected against sepsis-induced liver injury. Flow cytometry analysis revealed that these γδ T cells expressed Vγ4 TCR and migrated into liver from peripheral post CLP, in a CCR6-dependent manner. When CLP mice were treated with anti-CCR6 antibody to block CCR6-CCL20 axis, the recruitment of Vγ4+ γδ T cells was abolished, indicating a CCR6-dependent manner of migration. Interestingly, pseudo germ-free CLP mice treated with antibiotics showed that hepatic IL-17A+ γδ T cells were regulated by gut commensal microbes. Conclusion: Our research has shown that Vγ4+ IL-17A+ γδ T cells infiltrating into the liver play a crucial role in protecting against sepsis-induced liver injury. This protection was contingent upon the recruitment of CCR6 and regulated by gut commensal microbes.

Indexed as

Chemical and Drug Induced Liver Injury, ChronicIntraepithelial LymphocytesSepsisAnimalsEscherichia coliInterleukin-17MiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-Cell, gamma-deltaReceptors, CCR6CCR6 protein, mouseIl17a protein, mouseInterleukin-17Receptors, Antigen, T-Cell, gamma-deltaReceptors, CCR6CCR6gamma delta T cellsIL-17Aliver injurymicrobiotasepsis

Identifiers

PMID37475963
PMCPMC10354519
OpenAlexW4383198665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.