ArticleJournal of affective disorders reports2023
Adverse events in older adults and the risk of dementia and cognitive decline.
Article in Journal of affective disorders reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Comparison of the effects of choline alphoscerate and citicoline in patients with dementia disorders: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Prevalence of cognitive frailty in older adults with stroke in China: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- Adverse life events and cognition in older adults: the role of gender and psychological resilience.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Resting heart rate and cognitive function in ageing: Insights from a secondary data analysis.GeroScience · 2026Article
- Adverse Childhood Experiences and Life Course Adversity Related to Geriatric Syndromes: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Validation of the Japanese version of boredom proneness scale and derivation of its short version among older adults: a cross-sectional study.Health and quality of life outcomes · 2026Article
- Life-Course Psychosocial Stress and Risk of Dementia and Stroke in Middle-Aged and Older Adults.JAMA network open · 2026Article
- Big databases and biobanks for studying the links between CKD, cognitive impairment, and dementia.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Review
- Marital status and risk of dementia over 18 years: Surprising findings from the National Alzheimer's Coordinating Center.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Changes in Loneliness, Social Isolation, and Social Support: A Gender-Disaggregated Analysis of Their Associations With Dementia and Cognitive Decline in Older Adults.International journal of geriatric psychiatry · 2025Article
- Life Events and Incident Dementia: A Prospective Study of 493,787 Individuals Over 16 Years.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Effects of physical multimorbidity on cognitive decline trajectories among adults aged 50 years and older with different wealth status: a 17-year population-based cohort study.Global mental health (Cambridge, England) · 2024Article
- Distress Symptoms of Old Age and Mild Cognitive Impairment are Two Distinct Dimensions in Older Adults Without Major Depression.Psychology research and behavior management · 2024Article
- Negative Wealth Shock and Cognitive Decline and Dementia in Middle-Aged and Older US Adults.JAMA network open · 2023Article
- The association between adverse events in later life and mortality in older individuals.Comprehensive psychoneuroendocrinology · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Background: Increasing evidence suggests that stress could be a risk factor for dementia but this might vary by gender. This study investigated whether adverse life events were associated with cognitive decline and dementia in later-life, separately in men and women. Methods: Participants were 12,789 community-dwelling Australians aged ≥ 70 years. Ten common adverse events in later-life were self-reported. Cognitive decline was defined as a 1.5 SD decline from participants' baseline score in tests of global cognition, psychomotor speed, episodic memory, and executive functioning, which were assessed regularly over a maximum of 10.3 years. Dementia was diagnosed according to DSM-IV criteria. Results: An increased risk of dementia was observed in participants who experienced the death of a spouse/partner (HR: 1.72, 95% CI: 1.17 - 2.52) and for individuals who experienced major financial problems (HR: 1.53, 95% CI: 1.05 - 2.23). The latter also increased the risk of cognitive decline in men specifically (HR: 1.43, 95% CI: 1.10 - 1.86). In contrast, some events for women were associated with a reduced risk of dementia (e.g. close family or friends lost their job/retired (HR: 0.62, 95% CI: 0.40-0.95)). Limitations: Events including major money problems may result from prodromal dementia symptoms, thus reverse causation needs to be considered. Conclusions: Adverse life events may influence dementia risk in older adults, but associations vary depending on the nature of the event, and across genders. These findings support the need for early interventions in older people who have experienced adversities, particularly for the death of a loved one.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.