Evidence map›Paper›PMID 37475574›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2023

Peptide Macrocyclization Guided by Reversible Covalent Templating.

Josef M Maier, Stephanie A Valenzuela, Aevi van der Stok, Arjun K Menta, Yuka Shimizu, Phuoc H Ngo, Andrew D Ellington, Eric V Anslyn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Josef M MaierDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712, USA.ORCID https://orcid.org/0009-0001-4270-3498
Stephanie A ValenzuelaDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712, USA.ORCID https://orcid.org/0000-0002-0399-275X
Aevi van der StokDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712, USA.
Arjun K MentaDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712, USA.
Yuka ShimizuDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712, USA.
Phuoc H NgoDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712, USA.
Andrew D EllingtonDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712, USA.
Eric V AnslynDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712, USA.ORCID https://orcid.org/0000-0002-5137-8797

Funding

Bruker AVANCE III HD 500 MHz NMRS10OD021508 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI SESSLER, JONATHAN L · 2016 to 2016
$529k
NASA 80NSSC21K0479NIH HHS S10 OD021508
6 · The paper itself

Abstract

The creation of complementary products via templating is a hallmark feature of nucleic acid replication. Outside of nucleic acid-like molecules, the templated synthesis of a hetero-complementary copy is still rare. Herein we describe one cycle of templated synthesis that creates homomeric macrocyclic peptides guided by linear instructing strands. This strategy utilizes hydrazone formation to pre-organize peptide oligomeric monomers along the template on a solid support resin, and microwave-assisted peptide synthesis to couple monomers and cyclize the strands. With a flexible templating strand, we can alter the size of the complementary macrocycle products by increasing the length and number of the binding peptide oligomers, showing the potential to precisely tune the size of macrocyclic products. For the smaller macrocyclic peptides, the products can be released via hydrolysis and characterized by ESI-MS.

Indexed as

Nucleic AcidsPeptidesChemistry Techniques, SyntheticNucleic AcidsPeptidesdynamic covalent bondspeptidesreplicationsequence definedtemplating

Identifiers

PMID37475574
PMCPMC10592230

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.