Evidence map›Paper›PMID 37475558›Full record

ArticleCurrent neuropharmacology2024

Spatiomolecular Characterization of Dopamine D2 Receptors Cells in the Mouse External Globus Pallidus.

Julie Espallergues, Jihane Boubaker-Vitre, Audrey Mignon, Maelle Avrillon, Morgane Le Bon-Jego, Jerome Baufreton, Emmanuel Valjent

Open access · greenAbstract read
In one paragraph

Article in Current neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Cognitive functions of the GPe.Trends in neurosciences · 2026
    Review
  2. Effective Synthesis of Dopamine Dimer.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Julie EspallerguesIGF, University Montpellier, CNRS, Inserm, F-34094 Montpellier, France.
Jihane Boubaker-Vitre1IGF, University Montpellier, CNRS, Inserm, F-34094 Montpellier, France.
Audrey MignonIGF, University Montpellier, CNRS, Inserm, F-34094 Montpellier, France.
Maelle AvrillonIGF, University Montpellier, CNRS, Inserm, F-34094 Montpellier, France.
Morgane Le Bon-JegoUniversity Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France.
Jerome BaufretonUniversity Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France.
Emmanuel ValjentIGF, University Montpellier, CNRS, Inserm, F-34094 Montpellier, France.
Centre National de la Recherche Scientifique · FR

Funding

Agence National de la Recherche ANR-21-CE37-0013, ANR-20-CE14-0020, ANR-21-CE16-0028Inserm, Fondation Pour la Recherche Médicale EQU202203014705
6 · The paper itself

Abstract

The external globus pallidus (GPe) is part of the basal ganglia circuit and plays a key role in controlling the actions. Although, many evidence indicate that dopamine through its activation of dopamine D2 receptors (D2Rs) modulates the GPe neuronal activity, the precise spatiomolecular characterization of cell populations expressing D2Rs in the mouse GPe is still lacking. By combining single molecule in situ hybridization, cell type-specific imaging analyses, and electrophysiology slice recordings, we found that GPe D2R cells are neurons preferentially localized in the caudal portion of GPe. These neurons comprising pallido-striatal, pallido-nigral, and pallido-cortical neurons segregate into two distinct populations displaying molecular and electrophysiological features of GPe GABAergic PV/NKX2.1 and cholinergic neurons respectively. By clarifying the spatial molecular identity of GPe D2R neurons in the mouse, this work provides the basis for future studies aiming at disentangling the action of dopamine within the GPe.

Indexed as

Globus PallidusReceptors, Dopamine D2AnimalsMiceMice, Inbred C57BLMice, TransgenicNeuronsDRD2 protein, mouseReceptors, Dopamine D2cholinergic neuronsD2Rs.Dopamineglobus pallidusmousepallidostriatal

Identifiers

PMID37475558
PMCPMC11097984
OpenAlexW4384923255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.