Evidence map›Paper›PMID 37475472›Full record

ArticleJournal of dental research2023

MEMO1 Is Required for Ameloblast Maturation and Functional Enamel Formation.

M Kiel, S Wuebker, M T Remy, K A Riemondy, F Smith, C M Carey, T Williams, E Van Otterloo

Open access · greenAbstract read
In one paragraph

Article in Journal of dental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

M KielIowa Institute for Oral Health Research, University of Iowa, College of Dentistry & Dental Clinics, Iowa City, IA, USA.
S WuebkerIowa Institute for Oral Health Research, University of Iowa, College of Dentistry & Dental Clinics, Iowa City, IA, USA.
M T RemyIowa Institute for Oral Health Research, University of Iowa, College of Dentistry & Dental Clinics, Iowa City, IA, USA.
K A RiemondyRNA Bioscience Initiative, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
F SmithDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
C M CareyDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
T WilliamsDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
E Van OtterlooIowa Institute for Oral Health Research, University of Iowa, College of Dentistry & Dental Clinics, Iowa City, IA, USA.
University of Iowa · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Understanding the interaction of Memo1 and Runx2 in craniodental mineralizationR00DE026823 · NIDCR · UNIVERSITY OF IOWA · PI VAN OTTERLOO, ERIC · 2020 to 2022
$738k
Understanding the interaction of Memo1 and Runx2 in craniodental mineralizationK99DE026823 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI VAN OTTERLOO, ERIC · 2017 to 2018
$261k
NCI NIH HHS P30 CA046934NIDCR NIH HHS K99 DE026823NIDCR NIH HHS R00 DE026823
6 · The paper itself

Abstract

Coordinated mineralization of soft tissue is central to organismal form and function, while dysregulated mineralization underlies several human pathologies. Oral epithelial-derived ameloblasts are polarized, secretory cells responsible for generating enamel, the most mineralized substance in the human body. Defects in ameloblast development result in enamel anomalies, including amelogenesis imperfecta. Identifying proteins critical in ameloblast development can provide insight into specific pathologies associated with enamel-related disorders or, more broadly, mechanisms of mineralization. Previous studies identified a role for MEMO1 in bone mineralization; however, whether MEMO1 functions in the generation of additional mineralized structures remains unknown. Here, we identify a critical role for MEMO1 in enamel mineralization. First, we show that

Indexed as

AmeloblastsAmelogenesisDental EnamelAmelogenesis ImperfectaAnimalsCell DifferentiationMiceTooth Calcificationamelogenesisamelogenesis imperfectacell polaritycytoskeletonmineralizationtooth

Identifiers

PMID37475472
PMCPMC11066519
OpenAlexW4384925347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.