Evidence map›Paper›PMID 37475156›Full record

ArticleAnnals of clinical and translational neurology2023

Extent of piriform cortex resection in children with temporal lobe epilepsy.

Rory J Piper, Debayan Dasgupta, Maria H Eriksson, Mathilde Ripart, Almira Moosa, Aswin Chari, Kiran K Seunarine, Chris A Clark, John S Duncan, David W Carmichael and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Connectivity of the Piriform Cortex and its Implications in Temporal Lobe Epilepsy.medRxiv : the preprint server for health sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Rory J PiperDevelopmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0002-6422-5853
Debayan DasguptaDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID 0000-0002-1064-0541
Maria H ErikssonDevelopmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0001-6869-5804
Mathilde RipartDevelopmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0002-1761-5859
Almira MoosaDevelopmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.
Aswin ChariDevelopmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0003-0053-147X
Kiran K SeunarineDevelopmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.
Chris A ClarkDevelopmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.
John S DuncanDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID 0000-0002-1373-0681
David W CarmichaelDepartment of Biomedical Engineering, King's College London, London, UK.ORCID 0000-0001-9972-0718
Martin M TisdallDevelopmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0001-8880-8386
Torsten BaldewegDevelopmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0002-5724-1679
Great Ormond Street Hospital · GBEpilepsy Research UK · GBKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA greater extent of resection of the temporal portion of the piriform cortex (PC) has been shown to be associated with higher likelihood of seizure freedom in adults undergoing anterior temporal lobe resection (ATLR) for drug-resistant temporal lobe epilepsy (TLE). There have been no such studies in children, therefore this study aimed to investigate this association in a pediatric cohort.

methodsA retrospective, neuroimaging cohort study of children with TLE who underwent ATLR between 2012 and 2021 was undertaken. The PC, hippocampal and amygdala volumes were measured on the preoperative and postoperative T1-weighted MRI. Using these volumes, the extent of resection per region was compared between the seizure-free and not seizure-free groups.

resultsIn 50 children (median age 9.5 years) there was no significant difference between the extent of resection of the temporal PC in the seizure-free (median = 50%, n = 33/50) versus not seizure-free (median = 40%, n = 17/50) groups (p = 0.26). In a sub-group of 19 with ipsilateral hippocampal atrophy (quantitatively defined by ipsilateral-to-contralateral asymmetry), the median extent of temporal PC resection was greater in children who were seizure-free (53%) versus those not seizure-free (19%) (p = 0.009).

interpretationThis is the first study demonstrating that, in children with TLE and hippocampal atrophy, more extensive temporal PC resection is associated with a greater chance of seizure freedom-compatible with an adult series in which 85% of patients had hippocampal sclerosis. In a combined group of children with and without hippocampal atrophy, the extent of PC resection was not associated with seizure outcome, suggesting different epileptogenic networks within this cohort.

Indexed as

Drug Resistant EpilepsyEpilepsy, Temporal LobePiriform CortexAdultAtrophyChildCohort StudiesHumansMagnetic Resonance ImagingRetrospective Studies

Identifiers

PMID37475156
PMCPMC10502684
OpenAlexW4384925304

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.