ReviewThe Lancet. Respiratory medicine2023
Mitigating neurological, cognitive, and psychiatric sequelae of COVID-19-related critical illness.
Review in The Lancet. Respiratory medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Effects of traditional Chinese exercises or their integration with medical treatments on cognitive impairment: a network meta-analysis based on randomized controlled trials.Frontiers in aging neuroscience · 2024Pooled it
- Trial
- Article
- Psychiatric symptoms of long COVID among adults: observational case-control study in Johannesburg, South Africa.BJPsych open · 2026Article
- Prolonged dysregulation and pathological changes in the upper respiratory tract of SARS-CoV-2 infected hamsters.Npj viruses · 2026Article
- Mendelian randomization analyses support causal relationships between COVID-19 and changes in brain structure and function.European archives of psychiatry and clinical neuroscience · 2026Article
- Obesity and Nutritional Vulnerability in long COVID: A Neuroinflammatory and Cognitive Perspective.Current nutrition reports · 2026Review
- Risk of neurological and psychiatric diagnoses in COVID-19 survivors: A multicenter retrospective cohort study using electronic health records.World journal of psychiatry · 2025Article
- Non-invasive visualisation of long-lasting brain metabolic alterations in murine pseudo-infection model using parahydrogen-polarised [1-Discover nano · 2025Article
- Quality of life after ICU: 1-year follow-up in patients with and without COVID.Journal of anesthesia, analgesia and critical care · 2025Article
- Neuropsychiatric Manifestations of Long COVID-19: A Narrative Review of Clinical Aspects and Therapeutic Approaches.Life (Basel, Switzerland) · 2025Review
- Estimated prevalence of post-intensive care cognitive impairment at short-term and long-term follow-ups: a proportional meta-analysis of observational studies.Annals of intensive care · 2025Review
- How much is too much? A medication use evaluation of VA ICU sedation practice during the COVID-19 pandemic.PloS one · 2025Article
- Long COVID-related blood-brain barrier breakdown and microstructure in older adults are modified by sex and Alzheimer's disease genetic risk.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Omics-based analysis of mitochondrial dysfunction and BBB integrity in post-COVID-19 sequelae.Scientific reports · 2024Article
- Characterization of Change in Cognition Before and After COVID-19 Infection in Essential Workers at Midlife.American journal of medicine open · 2024Article
- Long Covid Defined.The New England journal of medicine · 2024Article
- Cerebral small vessel injury in mice with damage to ACE2-expressing cerebral vascular endothelial cells and post COVID-19 patients.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Socio-demographic and clinical predictors of post-acute, mid-and long-term psychological sequelae of COVID-19: a two-year cross-sectional investigation on 1317 patients at the University Hospital of Verona.Archives of public health = Archives belges de sante publique · 2024Article
- Prevalence and influencing factors of sleep disorders in medical students after the COVID-19 pandemic.BMC psychiatry · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Despite advances in the treatment and mitigation of critical illness caused by infection with SARS-CoV-2, millions of survivors have a devastating, post-acute infection syndrome known as long COVID. A large proportion of patients with long COVID have nervous system dysfunction, which is also seen in the distinct but overlapping condition of post-intensive care syndrome (PICS), putting survivors of COVID-19-related critical illness at high risk of long-lasting morbidity affecting multiple organ systems and, as a result, engendering measurable deficits in quality of life and productivity. In this Series paper, we discuss neurological, cognitive, and psychiatric sequelae in patients who have survived critical illness due to COVID-19. We review current knowledge of the epidemiology and pathophysiology of persistent neuropsychological impairments, and outline potential preventive strategies based on safe, evidence-based approaches to the management of pain, agitation, delirium, anticoagulation, and ventilator weaning during critical illness. We highlight priorities for current and future research, including possible therapeutic approaches, and offer considerations for health services to address the escalating health burden of long COVID.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.