Evidence map›Paper›PMID 37475035›Full record

ArticleJournal of translational medicine2023

Perspectives in Immunotherapy: meeting report from Immunotherapy Bridge (Naples, November 30th-December 1st, 2022).

Paolo A Ascierto, Antonio Avallone, Carlo Bifulco, Sergio Bracarda, Joshua D Brody, Leisha A Emens, Robert L Ferris, Silvia C Formenti, Omid Hamid, Douglas B Johnson and 14 more

Open access · goldAbstract readConference Proceedings
In one paragraph

Article in Journal of translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 19 institutions in 3 countries.

Paolo A AsciertoDepartment of Melanoma, Cancer Immunotherapy and Innovative Therapy, Istituto Nazionale Tumor IRCCS "Fondazione G. Pascale", Naples, Italy. paolo.ascierto@gmail.com.ORCID 0000-0002-8322-475X
Antonio AvalloneExperimental Clinical Abdominal Oncology Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy.
Carlo BifulcoTranslational Molecular Pathology and Molecular Genomics, Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Sergio BracardaDepartment of Oncology, Medical and Translational Oncology, Azienda Ospedaliera Santa Maria, Terni, Italy.
Joshua D BrodyTisch Cancer Institute, Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Leisha A EmensUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Robert L FerrisUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Silvia C FormentiWeill Cornell Medicine, New York, NY, USA.
Omid HamidThe Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate, Los Angeles, CA, USA.
Douglas B JohnsonDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Tomas KirchhoffLaura and Isaac Perlmutter Cancer Center, New York University (NYU) School of Medicine, NYU Langone Health, New York, NY, USA.
Christopher A KlebanoffMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Gregory B LesinskiDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.
Anne MonetteLady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Bart NeynsDepartment of Medical Oncology, University Hospital Brussel, Brussels, Belgium.
Kunle OdunsiUniversity of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, USA.
Chrystal M PaulosDepartment of Surgery and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Daniel J PowellCenter for Cellular Immunotherapies, Department of Pathology and Laboratory Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Katayoun RezvaniDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Brahm H SegalDepartment of Internal Medicine and Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Nathan SinghDivision of Oncology, Washington University School of Medicine, Saint Louis, MO, USA.
Ryan J SullivanMelanoma Program, Massachusetts General Hospital Cancer Center, Boston, MA, USA.
Bernard A FoxRobert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Igor PuzanovDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Emory University · USIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITProvidence Portland Medical Center · USRoswell Park Comprehensive Cancer Center · USAkebia Therapeutics (United States) · USAngeles Clinic and Research Institute · USAzienda Ospedaliera S.Maria · ITCornell University · USJewish General Hospital · CAMassachusetts General Hospital · USMemorial Sloan Kettering Cancer Center · USNYU Langone Health · USThe University of Texas MD Anderson Cancer Center · USTisch Hospital · USUniversity of Chicago · USUniversity of Pennsylvania · USUPMC Hillman Cancer Center · USVanderbilt University Medical Center · USWashington University in St. Louis · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Molecular mechanisms of T cell responses to a clonal neoantigen resulting from a mutated driver oncogene.R37CA259177 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Christopher Austin Klebanoff · 2021 to 2026
$3.1M
NCI NIH HHS P30 CA008748NCI NIH HHS R37 CA259177
6 · The paper itself

Abstract

The discovery and development of novel treatments that harness the patient's immune system and prevent immune escape has dramatically improved outcomes for patients across cancer types. However, not all patients respond to immunotherapy, acquired resistance remains a challenge, and responses are poor in certain tumors which are considered to be immunologically cold. This has led to the need for new immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and novel immune checkpoint inhibitors. These new approaches are focused on patients with an inadequate response to current treatments, with emerging evidence of improved responses in various cancers with new immunotherapy agents, often in combinations with existing agents. The use of cell therapies, drivers of immune response, and trends in immunotherapy were the focus of the Immunotherapy Bridge (November 30th-December 1st, 2022), organized by the Fondazione Melanoma Onlus, Naples, Italy, in collaboration with the Society for Immunotherapy of Cancer.

Indexed as

MelanomaHumansImmunotherapyImmunotherapy, AdoptiveItalyTumor MicroenvironmentBiomarkersCheckpoint inhibitorsCombination therapyImmunotherapyTumor microenvironmentVaccine

Identifiers

PMID37475035
PMCPMC10360352
OpenAlexW4384925159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.