Evidence map›Paper›PMID 37474951›Full record

ArticleBiomedical engineering online2023

Printing tissue-engineered scaffolds made of polycaprolactone and nano-hydroxyapatite with mechanical properties appropriate for trabecular bone substitutes.

Zahra Yazdanpanah, Nitin Kumar Sharma, Alice Raquin, David M L Cooper, Xiongbiao Chen, James D Johnston

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical engineering online, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Zahra YazdanpanahDivision of Biomedical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada. zay413@mail.usask.ca.
Nitin Kumar SharmaDepartment of Mechanical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada.
Alice RaquinDivision of Biomedical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada.
David M L CooperDepartment of Anatomy, Physiology, and Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Xiongbiao ChenDivision of Biomedical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada.ORCID http://orcid.org/0000-0002-4716-549X
James D JohnstonDivision of Biomedical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada.
University of Saskatchewan · CAInstitut Catholique d'Arts et Métiers · FR

Funding

Natural Science and Engineering Research Council of Canada RGPIN-2019-06396Natural Sciences and Engineering Research Council of Canada RGPIN-2015-06420Natural Sciences and Engineering Research Council of Canada RGPIN-2020-06043
6 · The paper itself

Abstract

backgroundBone tissue engineering, based on three-dimensional (3D) printing technology, has emerged as a promising approach to treat bone defects using scaffolds. The objective of this study was to investigate the influence of porosity and internal structure on the mechanical properties of scaffolds.

methodsWe fabricated composite scaffolds (which aimed to replicate trabecular bone) from polycaprolactone (PCL) reinforced with 30% (wt.) nano-hydroxyapatite (nHAp) by extrusion printing. Scaffolds with various porosities were designed and fabricated with and without an interlayer offset, termed as staggered and lattice structure, respectively. Mechanical compressive testing was performed to determine scaffold elastic modulus and yield strength. Linear regression was used to evaluate mechanical properties as a function of scaffold porosity.

resultsDifferent relationships between mechanical properties and porosities were noted for the staggered and lattice structures. For elastic moduli, the two relationships intersected (porosity = 55%) such that the lattice structure exhibited higher moduli with porosity values greater than the intersection point; vice versa for the staggered structure. The lattice structure exhibited higher yield strength at all porosities. Mechanical testing results also indicated elastic moduli and yield strength properties comparable to trabecular bone (elastic moduli: 14-165 MPa; yield strength: 0.9-10 MPa).

conclusionsTaken together, this study demonstrates that scaffolds printed from PCL/30% (wt.) nHAp with lattice and staggered structure offer promise for treating trabecular bone defects. This study identified the effect of porosity and internal structure on scaffold mechanical properties and provided suggestions for developing scaffolds with mechanical properties for substituting trabecular bone.

Indexed as

Bone SubstitutesDurapatitePolyestersPorosityPrinting, Three-DimensionalPyrenesTissue EngineeringTissue ScaffoldsBone SubstitutesDurapatiteN-hydroxy-2-aminopyrenepolycaprolactonePolyestersPyrenesBone scaffoldLattice structureNano-hydroxyapatitePolycaprolactoneStaggered structureThree-dimensional printing

Identifiers

PMID37474951
PMCPMC10360269
OpenAlexW4384925479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.