Evidence map›Paper›PMID 37474840›Full record

ArticleNetherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation2023

Exercise does not influence development of phenotype in PLN p.(Arg14del) cardiomyopathy.

Freyja H M van Lint, Fahima Hassanzada, Tom E Verstraelen, Weijia Wang, Laurens P Bosman, Paul A van der Zwaag, Toon Oomen, Hugh Calkins, Brittney Murray, Crystal Tichnell and 7 more

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In one paragraph

Article in Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Genetic landscape of phospholamban cardiomyopathies.Frontiers in cell and developmental biology · 2025
    Review
  10. Deletion of DWORF does not affect cardiac function in aging and in PLN-R14del cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  11. "When you see a fork in the road, take it"-Yogi Berra.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Freyja H M van LintDepartment of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Fahima HassanzadaDepartment of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Tom E VerstraelenHeart Centre, Department of Cardiology, Amsterdam University Medical Centre, location Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
Weijia WangDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Laurens P BosmanNetherlands Heart Institute, Utrecht, The Netherlands.
Paul A van der ZwaagUniversity Medical Centre Groningen, Department of Genetics, University of Groningen, Groningen, The Netherlands.
Toon OomenDepartment of Cardiology, St. Antonius Hospital, Sneek, The Netherlands.
Hugh CalkinsDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Brittney MurrayDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Crystal TichnellDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Thais M A BeurenDepartment of Human Genetics, Amsterdam University Medical Centres, location Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
Folkert W AsselbergsDepartment of Cardiology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Arjan HouwelingDepartment of Human Genetics, Amsterdam University Medical Centres, location Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
Maarten P van den BergDepartment of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Arthur A M WildeHeart Centre, Department of Cardiology, Amsterdam University Medical Centre, location Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
Cynthia A JamesDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
J Peter van TintelenDepartment of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands. j.p.vantintelen-3@umcutrecht.nl.
University of Amsterdam · NLJohns Hopkins Medicine · USUtrecht University · NLJohns Hopkins University · USUniversity Medical Center Groningen · NLNetherlands Heart Institute · NLSt. Antonius Ziekenhuis · NL

Funding

Fondation Leducq CUREPLaNHartstichting several: see text articlaHartstichting several: see text article
6 · The paper itself

Abstract

backgroundEndurance and frequent exercise are associated with earlier onset of arrhythmogenic right ventricular cardiomyopathy (ARVC) and ventricular arrhythmias (VA) in desmosomal gene variant carriers. Individuals with the pathogenic c.40_42del; p.(Arg14del) variant in the PLN gene are frequently diagnosed with ARVC or dilated cardiomyopathy (DCM). The aim of this study was to evaluate the effect of exercise in PLN p.(Arg14del) carriers.

methodsIn total, 207 adult PLN p.(Arg14del) carriers (39.1% male; mean age 53 ± 15 years) were interviewed on their regular physical activity since the age of 10 years. The association of exercise with diagnosis of ARVC, DCM, sustained VA and hospitalisation for heart failure (HF) was studied.

resultsIndividuals participated in regular physical activities with a median of 1661 metabolic equivalent of task (MET) hours per year (31.9 MET-hours per week) until clinical presentation. The 50% most and least active individuals had a similar frequency of sustained VA (18.3% vs 18.4%; p = 0.974) and hospitalisation for HF (9.6% vs 8.7%; p = 0.827). There was no relationship between exercise and survival free from (incident) sustained VA (p = 0.65), hospitalisation for HF (p = 0.81), diagnosis of ARVC (p = 0.67) or DCM (p = 0.39) during follow-up. In multivariate analyses, exercise was not associated with sustained VA or HF hospitalisation during follow-up in this relatively not-active cohort.

conclusionThere was no association between the amount of exercise and the susceptibility to develop ARVC, DCM, VA or HF in PLN p.(Arg14del) carriers. This suggested unaffected PLN p.(Arg14del) carriers can safely perform mild-moderate exercise, in contrast to desmosomal variant carriers and ARVC patients.

Indexed as

Arrhythmogenic right ventricular cardiomyopathyDilated cardiomyopathyExerciseGeneticsPenetrance

Identifiers

PMID37474840
PMCPMC10400740
OpenAlexW4384922384

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.