ArticleCommunications biology2023
Age-related changes in circadian regulation of the human plasma lipidome.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The TyrRS cascade: circadian gating of neuronal DNA repair and its collapse in aging.GeroScience · 2026Review
- Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple sclerosis.Neuron · 2026Article
- Rhythmic Metabolism in Osteosarcopenia: Emerging Evidence, a Chronometabolomic Framework for the Bone-Muscle Unit, and Research Priorities.Metabolites · 2026Review
- Depression trajectories and their associations with academic performance and sleep patterns among first-year college students.BMC psychology · 2026Article
- Influence of Seasonal and Chronobiological Factors on Driver Behavior and Traffic Accident Risk: A Scoping Review.Sleep science (Sao Paulo, Brazil) · 2026Review
- Differential effects of sex and age on daily and infradian rhythms of mice.The Journal of physiology · 2026Article
- Review
- Quantitative lipidomics reveals Lipid perturbation of plasma apoptotic extracellular vesicles during physiological aging.Frontiers in cell and developmental biology · 2026Article
- Circadian Rhythms in Aging and Age-Related Neurogenerative Disease.Current sleep medicine reports · 2025Article
- Circadian rhythms and the light-dark cycle interact to regulate amyloid-beta plaque accumulation and tau phosphorylation in 5xFAD mice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Multifaceted dynamics of circadian timing system influence aging and longevity.Biogerontology · 2025Review
- Circadian rhythms and the light-dark cycle interact to regulate amyloid plaque accumulation and tau phosphorylation in 5xFAD mice.bioRxiv : the preprint server for biology · 2025Article
- Article
- Circadian ontogenetic metabolomics atlas: an interactive resource with insights from rat plasma, tissues, and feces.Cellular and molecular life sciences : CMLS · 2025Article
- Circadian system and aging: where both times interact.Frontiers in aging · 2025Review
- Lipid metabolism and osteonecrosis: unraveling causal mechanisms via multi-omics and mendelian randomization.Frontiers in physiology · 2025Article
- Bayesian Covariate-Dependent Circadian Modeling of Rest-Activity Rhythms.Data science in science · 2025Article
- Circadian Rhythm of Distal Skin Temperature in Healthy Older and Young Women and Its Relationship with Sleep-Wake Rhythm and Environmental Factors under Natural Living Conditions.Geriatrics (Basel, Switzerland) · 2024Article
- Circadian rhythm analysis using wearable-based accelerometry as a digital biomarker of aging and healthspan.NPJ digital medicine · 2024Article
- Circadian protein expression patterns in healthy young adults.Sleep health · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Aging alters the amplitude and phase of centrally regulated circadian rhythms. Here we evaluate whether peripheral circadian rhythmicity in the plasma lipidome is altered by aging through retrospective lipidomics analysis on plasma samples collected in 24 healthy individuals (9 females; mean ± SD age: 40.9 ± 18.2 years) including 12 younger (4 females, 23.5 ± 3.9 years) and 12 middle-aged older, (5 females, 58.3 ± 4.2 years) individuals every 3 h throughout a 27-h constant routine (CR) protocol, which allows separating evoked changes from endogenously generated oscillations in physiology. Cosinor regression shows circadian rhythmicity in 25% of lipids in both groups. On average, the older group has a ~14% lower amplitude and a ~2.1 h earlier acrophase of the lipid circadian rhythms (both, p ≤ 0.001). Additionally, more rhythmic circadian lipids have a significant linear component in addition to the sinusoidal across the 27-h CR in the older group (44/56) compared to the younger group (18/58, p < 0.0001). Results from individual-level data are consistent with group-average results. Results indicate that prevalence of endogenous circadian rhythms of the human plasma lipidome is preserved with healthy aging into middle-age, but significant changes in rhythmicity include a reduction in amplitude, earlier acrophase, and an altered temporal relationship between central and lipid rhythms.
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