ArticleLa Radiologia medica2023
Resting-state functional magnetic resonance imaging study comparing tremor-dominant and postural instability/gait difficulty subtypes of Parkinson's disease.
Article in La Radiologia medica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Relationship between excessive daytime sleepiness and motor subtype transition in untreated prodromal Parkinson's disease: a cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Similar DTI-ALPS metrics in Parkinson's disease and essential tremor: a cross-sectional comparative analysis.Neuroradiology · 2026Article
- An exploratory study of altered regional homogeneity in Parkinson's disease with depression.Frontiers in psychiatry · 2026Article
- Altered static and dynamic intrinsic brain activity patterns in type 2 diabetic patients.Scientific reports · 2025Article
- Thalamic functional connectivity on 7-Tesla magnetic resonance imaging and its relation to motor signs in early-stage Parkinson's disease.Quantitative imaging in medicine and surgery · 2025Article
- Network localization of regional homogeneity alterations in Parkinson's disease.Frontiers in aging neuroscience · 2025Article
- Individual-specific metabolic network based onHuman brain mapping · 2024Article
- Resting-state functional connectivity of the occipital cortex in different subtypes of Parkinson's disease.CNS neuroscience & therapeutics · 2024Article
- Altered connectivity between frontal cortex and supplementary motor area in various types of Parkinson's disease.American journal of translational research · 2024Article
- Early re-emerging tremor after MRgFUS thalamotomy: case-control analysis of procedural and imaging features.Frontiers in neurology · 2024Article
- Auto-Classification of Parkinson's Disease with Different Motor Subtypes Using Arterial Spin Labelling MRI Based on Machine Learning.Brain sciences · 2023Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe symptom-specific intrinsic neural mechanisms underlying Parkinson's disease (PD) subtypes (tremor dominant [TD] and postural instability gait difficulty [PIGD]) remain unclarified. We examined spontaneous brain activity patterns in TD and PIGD. MATERIAL AND
methodsWe included 49 patients with PD (21 with TD/28 with PIGD) and 32 healthy controls (HCs) in this study. We conducted analysis of variance and post-hoc analyses of the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) values of the three groups, with age, sex, and gray matter volume as covariates, and a relationship analysis of the ALFF and ReHo values with clinical variables.
resultsIn comparison with HCs, PIGD PD patients had increased ALFF values in the right middle occipital gyrus and left superior occipital gyrus and decreased values primarily in the bilateral inferior frontal gyrus (triangular part). TD PD patients had lower ALFF values in the right inferior frontal gyrus (triangular part) and left insula. In comparison to TD PD patients, PIGD PD patients had higher ALFF values in the left middle occipital gyrus and left superior occipital gyrus. In contrast to HCs, TD PD patients demonstrated a reduction of ReHo values in the left middle temporal gyrus, and PIGD patients showed a decrease of ReHo values in the left inferior temporal gyrus.
conclusionALFF values increased in the occipital gyrus of the PIGD PD patients, thus providing evidence of a compensatory mechanism of altered motor function in comparison with the TD PD patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.