Evidence map›Paper›PMID 37474653›Full record

ArticleNature immunology2023

mRNA vaccine against malaria tailored for liver-resident memory T cells.

Mitch Ganley, Lauren E Holz, Jordan J Minnell, Maria N de Menezes, Olivia K Burn, Kean Chan Yew Poa, Sarah L Draper, Kieran English, Susanna T S Chan, Regan J Anderson and 20 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 63 citations in OpenAlex.

  1. Review
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  4. CD8MedComm · 2026
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  14. Immunology of RNA-based vaccines: The critical interplay between inflammation and expression.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  15. Tissue-resident memory CD8Nature reviews. Gastroenterology & hepatology · 2025
    Review
  16. Article
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  18. mRNA-LNP vaccine encoding theMolecular therapy. Nucleic acids · 2025
    Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 8 institutions in 4 countries.

Mitch Ganley *Ferrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand.
Lauren E Holz *Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0003-4897-0981
Jordan J MinnellMalaghan Institute of Medical Research, Wellington, New Zealand.ORCID http://orcid.org/0000-0001-9108-7874
Maria N de MenezesDepartment of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.
Olivia K BurnMalaghan Institute of Medical Research, Wellington, New Zealand.ORCID http://orcid.org/0000-0003-1130-0220
Kean Chan Yew PoaInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Sarah L DraperFerrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand.ORCID http://orcid.org/0000-0001-8330-121X
Kieran EnglishCentenary Institute and University of Sydney, AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Susanna T S ChanFerrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand.
Regan J AndersonFerrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand.
Benjamin J ComptonFerrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand.
Andrew J MarshallFerrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand.ORCID http://orcid.org/0000-0003-0022-2001
Anton CozijnsenSchool of BioSciences, University of Melbourne, Parkville, Victoria, Australia.
Yu Cheng ChuaDepartment of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.
Zhengyu GeDepartment of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-8735-5335
Kathryn J FarrandMalaghan Institute of Medical Research, Wellington, New Zealand.
John C MamumMalaghan Institute of Medical Research, Wellington, New Zealand.
Calvin XuDepartment of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0003-0753-7639
Ian A CockburnDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0001-8220-9294
Katsuyuki YuiShionogi Global Infectious Diseases Division, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, Japan.ORCID http://orcid.org/0000-0003-1130-2496
Patrick BertolinoCentenary Institute and University of Sydney, AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-8244-7057
Stephanie GrasInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0001-7416-038X
Jérôme Le NoursInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Jamie RossjohnInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0002-2020-7522
Daniel Fernandez-RuizDepartment of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-4040-9121
Geoffrey I McFaddenSchool of BioSciences, University of Melbourne, Parkville, Victoria, Australia.
David F AckerleyMaurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.ORCID http://orcid.org/0000-0002-6188-9902
Gavin F PainterFerrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand. gavin.painter@vuw.ac.nz.ORCID http://orcid.org/0000-0002-1310-7769
Ian F HermansMaurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand. ihermans@malaghan.org.nz.ORCID http://orcid.org/0000-0002-7584-887X
William R HeathDepartment of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia. wrheath@unimelb.edu.au.ORCID http://orcid.org/0000-0001-9670-259X
The University of Melbourne · AUVictoria University of Wellington · NZMalaghan Institute of Medical Research · NZAustralian Regenerative Medicine Institute · AURoyal Prince Alfred Hospital · AUAustralian National University · AULa Trobe University · AUNagasaki University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive replication occurs, emerging later as merozoites that can infect red blood cells and cause symptoms of disease. As liver tissue-resident memory T cells (Trm cells) have recently been shown to control liver-stage infections, we embarked on a messenger RNA (mRNA)-based vaccine strategy to induce liver Trm cells to prevent malaria. Although a standard mRNA vaccine was unable to generate liver Trm or protect against challenge with Plasmodium berghei sporozoites in mice, addition of an agonist that recruits T cell help from type I natural killer T cells under mRNA-vaccination conditions resulted in significant generation of liver Trm cells and effective protection. Moreover, whereas previous exposure of mice to blood-stage infection impaired traditional vaccines based on attenuated sporozoites, mRNA vaccination was unaffected, underlining the potential for such a rational mRNA-based strategy in malaria-endemic regions.

Indexed as

MalariaMalaria VaccinesAnimalsCD8-Positive T-LymphocytesLiverMemory T CellsMicePlasmodium bergheiMalaria Vaccines

Identifiers

PMID37474653
OpenAlexW4384924281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.