Evidence map›Paper›PMID 37474575›Full record

ArticleNature communications2023

Neural signatures of social inferences predict the number of real-life social contacts and autism severity.

Anita Tusche, Robert P Spunt, Lynn K Paul, Julian M Tyszka, Ralph Adolphs

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Functional Brain Asymmetry Reveals Heterogeneous Subtypes in Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Anita TuscheDivision of the Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, 91125, USA. anita.tusche@gmail.com.ORCID 0000-0003-4180-8447
Robert P SpuntDivision of the Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, 91125, USA.ORCID 0000-0003-2975-4597
Lynn K PaulDivision of the Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, 91125, USA.ORCID 0000-0002-3128-8313
Julian M TyszkaDivision of the Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, 91125, USA.ORCID 0000-0001-9342-9014
Ralph AdolphsDivision of the Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, 91125, USA.ORCID 0000-0002-8053-9692
California Institute of Technology · US

Funding

The Neurobiology of Social Decision-Making: Social Inference and ContextP50MH094258 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ADOLPHS, RALPH · 2012 to 2021
$18.6M
NIMH NIH HHS P50 MH094258
6 · The paper itself

Abstract

We regularly infer other people's thoughts and feelings from observing their actions, but how this ability contributes to successful social behavior and interactions remains unknown. We show that neural activation patterns during social inferences obtained in the laboratory predict the number of social contacts in the real world, as measured by the social network index, in three neurotypical samples (total n = 126) and one sample of autistic adults (n = 23). We also show that brain patterns during social inference generalize across individuals in these groups. Cross-validated associations between brain activations and social inference localize selectively to the right posterior superior temporal sulcus and were specific for social, but not nonsocial, inference. Activation within this same brain region also predicts autism-like trait scores from questionnaires and autism symptom severity. Thus, neural activations produced while thinking about other people's mental states predict variance in multiple indices of social functioning in the real world.

Indexed as

Autistic DisorderAdultBrainHumansMagnetic Resonance ImagingSocial BehaviorTemporal Lobe

Identifiers

PMID37474575
PMCPMC10359299
OpenAlexW4384925203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.