ArticleNature communications2023
Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Placebo Effect of Sham Acupuncture for Primary Insomnia: A Meta-Analysis of Randomised Controlled Trials.Journal of sleep research · 2026Pooled it
- Computational origins of cortical brain circuits for social cognition.Nature reviews. Neuroscience · 2026Review
- Primate neuroethology: a new synthesis.Trends in cognitive sciences · 2026Review
- Understanding the Brain as a Mentalizing Machine with a Symbol Grounding Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Clarifying the neural circuit mechanisms of spontaneous social behavior in macaques.Frontiers in neural circuits · 2026Article
- Advances in chemogenetics: a review of DREADDs and its application in psychiatric disorders.Molecular psychiatry · 2026Review
- How dopamine guides our social world.Pharmacological reviews · 2025Review
- Frontal-auditory cortical interactions and sensory prediction during vocal production in marmoset monkeys.Current biology : CB · 2025Article
- Imaging-based chemogenetics for dissecting neural circuits in nonhuman primates.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2024Review
- Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques.Nature communications · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The value of one's own reward is affected by the reward of others, serving as a source for envy. However, it is not known which neural circuits mediate such socially subjective value modulation. Here, we chemogenetically dissected the circuit from the medial prefrontal cortex (MPFC) to the lateral hypothalamus (LH) while male macaques were presented with visual stimuli that concurrently signaled the prospects of one's own and others' rewards. We found that functional disconnection between the MPFC and LH rendered animals significantly less susceptible to others' but not one's own reward prospects. In parallel with this behavioral change, inter-areal coordination, as indexed by coherence and Granger causality, decreased primarily in the delta and theta bands. These findings demonstrate that the MPFC-to-LH circuit plays a crucial role in carrying information about upcoming other-rewards for subjective reward valuation in social contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.