Evidence map›Paper›PMID 37474513›Full record

ArticleNature communications2023

Structures of channelrhodopsin paralogs in peptidiscs explain their contrasting K

Takefumi Morizumi, Kyumhyuk Kim, Hai Li, Elena G Govorunova, Oleg A Sineshchekov, Yumei Wang, Lei Zheng, Éva Bertalan, Ana-Nicoleta Bondar, Azam Askari and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Blue-shifted ancyromonad channelrhodopsins for multiplex optogenetics.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Article
  11. Structural insights into CXCR4 modulation and oligomerization.Nature structural & molecular biology · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Takefumi Morizumi *Department of Biochemistry, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-2785-209X
Kyumhyuk Kim *Department of Biochemistry, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-1870-7296
Hai Li *Department of Biochemistry & Molecular Biology, Center for Membrane Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA.ORCID 0000-0002-3969-6709
Elena G Govorunova *Department of Biochemistry & Molecular Biology, Center for Membrane Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA.ORCID 0000-0003-0522-9683
Oleg A SineshchekovDepartment of Biochemistry & Molecular Biology, Center for Membrane Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA.ORCID 0000-0002-6358-7764
Yumei WangDepartment of Biochemistry & Molecular Biology, Center for Membrane Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA.
Lei ZhengDepartment of Biochemistry & Molecular Biology, Center for Membrane Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA.ORCID 0000-0001-7789-5234
Éva BertalanPhysikzentrum, RWTH-Aachen University, Aachen, Germany.ORCID 0000-0003-1673-5178
Ana-Nicoleta BondarFaculty of Physics, University of Bucharest, Măgurele, Romania.
Azam AskariDepartment of Physics and Biophysics Interdepartmental Group, University of Guelph, Guelph, ON, Canada.ORCID 0009-0008-8917-7262
Leonid S BrownDepartment of Physics and Biophysics Interdepartmental Group, University of Guelph, Guelph, ON, Canada.ORCID 0000-0002-5614-8317
John L SpudichDepartment of Biochemistry & Molecular Biology, Center for Membrane Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA. john.l.spudich@uth.tmc.edu.ORCID 0000-0003-4167-8590
Oliver P ErnstDepartment of Biochemistry, University of Toronto, Toronto, ON, Canada. oliver.ernst@utoronto.ca.ORCID 0000-0002-8863-9444
The University of Texas Health Science Center at Houston · USUniversity of Toronto · CAUniversity of Guelph · CARWTH Aachen University · DEThe University of Texas Health Science Center · USUniversity of Bucharest · RO

Funding

Molecular Engineering of Natural Light-Gated Chloride Channels for Optogenetic InhibitionU01NS118288 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SPUDICH, JOHN LEE, ST-PIERRE, FRANCOIS · 2020 to 2023
$5.2M
Structure/Function of Channelrhodopsins and Related Retinylidene ProteinsR35GM140838 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SPUDICH, JOHN LEE · 2021 to 2025
$3.1M
Structure and function of a metabolic pacemaker in bacterial cell membraneR01GM143418 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHENG, LEI · 2021 to 2024
$1.5M
NIGMS NIH HHS R01 GM143418NIGMS NIH HHS R35 GM140838NINDS NIH HHS U01 NS118288
6 · The paper itself

Abstract

Kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) is a light-gated channel used for optogenetic silencing of mammalian neurons. It selects K

Indexed as

MammalsAnimalsCationsChannelrhodopsinsCryoelectron MicroscopyCationsChannelrhodopsins

Identifiers

PMID37474513
PMCPMC10359266
OpenAlexW4384924590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.