Evidence map›Paper›PMID 37474311›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Postsynaptic Calcium Extrusion at the Mouse Neuromuscular Junction Alkalinizes the Synaptic Cleft.

Ryan J Durbin, Dante J Heredia, Thomas W Gould, Robert B Renden

Open access · hybridAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. A dangerous liaison: Spreading depolarization and tissue acidification in cerebral ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ryan J DurbinIntegrative Neuroscience Graduate Program, University of Nevada, Reno, Reno, Nevada 89557.
Dante J HerediaDepartment of Physiology and Cell Biology, University of Nevada, Reno, School of Medicine, Reno, Nevada 89557.
Thomas W GouldIntegrative Neuroscience Graduate Program, University of Nevada, Reno, Reno, Nevada 89557.
Robert B RendenIntegrative Neuroscience Graduate Program, University of Nevada, Reno, Reno, Nevada 89557 rendenr@unr.edu.ORCID 0000-0001-7905-4789
University of Nevada, Reno · US

Funding

Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Andreia Nunes · 2019 to 2026
$20.3M
Activity-dependent energy homeostasis at the presynaptic terminalR01NS117686 · NINDS · UNIVERSITY OF NEVADA RENO · PI RENDEN, ROBERT B · 2020 to 2022
$1.6M
NIGMS NIH HHS P20 GM130459NINDS NIH HHS R01 NS117686
6 · The paper itself

Abstract

Neurotransmission is shaped by extracellular pH. Alkalization enhances pH-sensitive transmitter release and receptor activation, whereas acidification inhibits these processes and can activate acid-sensitive conductances in the synaptic cleft. Previous work has shown that the synaptic cleft can either acidify because of synaptic vesicular release and/or alkalize because of Ca

Indexed as

CalciumSynapsesAnimalsCholinergic AgentsFemaleMaleMammalsMiceNeuromuscular JunctionSynaptic TransmissionCalciumCholinergic Agentsacetylcholinemouseneuromuscular junctionpHsynapsesynaptic transmission

Identifiers

PMID37474311
PMCPMC10423045
OpenAlexW4384926679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.