Evidence map›Paper›PMID 37474270›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2023

Detection of IL12/23p40 via PET Visualizes Inflammatory Bowel Disease.

Farzaneh Rezazadeh, Nicholas Ramos, Allen-Dexter Saliganan, Najeeb Al-Hallak, Kang Chen, Bashar Mohamad, Wendy N Wiesend, Nerissa T Viola

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Gut-reproduction axis: genome-wide pleiotropic and prospective evidence linking inflammatory bowel disease with gynecological disorders.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Key Interleukins in Inflammatory Bowel Disease-A Review of Recent Studies.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Imaging Agents for PET of Inflammatory Bowel Disease: A Review.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Farzaneh RezazadehDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
Nicholas RamosDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
Allen-Dexter SaligananDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
Najeeb Al-HallakDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
Kang ChenDepartments of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan.
Bashar MohamadDepartment of Gastroenterology, Wayne State University, Detroit, Michigan; and.
Wendy N WiesendDepartment of Anatomic Pathology, Corewell Health William Beaumont University Hospital, Royal Oak, Michigan.
Nerissa T ViolaDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan; violan@karmanos.org.
Wayne State University · USThe Barbara Ann Karmanos Cancer Institute · US

Funding

Delineating Functional Immunity via Image-Guided PETR37CA220482 · NCI · WAYNE STATE UNIVERSITY · PI GIBSON, HEATHER MARIE, VIOLA, NERISSA THERESE · 2018 to 2024
$3.9M
NCI NIH HHS R37 CA220482
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD), which includes both Crohn disease and ulcerative colitis, is a relapsing inflammatory disease of the gastrointestinal tract. Long-term chronic inflammatory conditions elevate the patient's risk of colorectal cancer (CRC). Currently, diagnosis requires endoscopy with biopsy. This procedure is invasive and requires a bowel-preparatory regimen, adding to patient burden. Interleukin 12 (IL12) and interleukin 23 (IL23) play key roles in inflammation, especially in the pathogenesis of IBD, and are established therapeutic targets. We propose that imaging of IL12/23 and its p40 subunit in IBD via immuno-PET potentially provides a new noninvasive diagnostic approach.

Indexed as

ColitisInflammatory Bowel DiseasesAnimalsDextransDextran SulfateDisease Models, AnimalHumansInflammationInterleukin-12MicePositron-Emission TomographySulfatesDextransDextran SulfateInterleukin-12sodium sulfateSulfatescolitisIL12/23p40immuno-PETinflammatory bowel disease

Identifiers

PMID37474270
PMCPMC10626378
OpenAlexW4384926586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.