ArticleContemporary clinical trials2023
Study protocol for the ROSE Scale-Up Study: Informing a decision about ROSE as universal postpartum depression prevention.
Article in Contemporary clinical trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
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Who cites it
6 citing papers in PubMed.
- Outcomes of the ROSE Sustainment (ROSES) Study, a sequential multiple assignment randomized implementation trial to determine the minimum necessary intervention to sustain a postpartum depression prevention program in agencies serving low-income pregnant people.Implementation science : IS · 2025Trial
- Enduring effects of brief interpersonal therapy on depression from pregnancy through 1-year postpartum: A randomized clinical trial.Journal of mood and anxiety disorders · 2026Article
- Perinatal mental health care goes digital: Opportunities for digital health to revolutionize the care delivery for healthier pregnancies and outcomes.PLOS digital health · 2025Article
- A method for predicting postpartum depression via an ensemble neural network model.Frontiers in public health · 2025Article
- Leveraging the interpersonal context of child development to promote family resilience: A universal prevention approach from preconception through early childhood.Mental health & prevention · 2024Article
- Safe Babies Safe Moms Women's and Infants' Services Perinatal Mental Health and Wellness Program: A Comprehensive Integrated Model for Prevention and Treatment.Journal of midwifery & women's healthArticle
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Authors and funding
7 authors.
Funding
Abstract
purposeTo examine the effectiveness, cost-outcome, equity, scalability, and mechanisms of the Reach Out, Stay strong, Essentials for mothers of newborns (ROSE) postpartum depression prevention (PPD) program as universal versus selective or indicated prevention.
backgroundThe United States Preventive Services Task Force (USPSTF) currently recommends PPD prevention for pregnant people at risk of PPD (i.e., selective/indicated prevention). However, universal prevention may be more scalable, equitable, and cost-beneficial.
designEffectiveness of ROSE for preventing PPD among people at risk is known. To assess ROSE as universal prevention, we need to determine the effectiveness of ROSE among all pregnant people, including those screening negative for PPD risk. We will enroll 2320 pregnant people, assess them with commonly available PPD risk prediction tools, randomize everyone to ROSE or enhanced care as usual, and assess ROSE as universal, selective, and indicated prevention in terms of: (1) effectiveness (PPD prevention and functioning), (2) cost-benefit, (3) equity (PPD cases prevented by universal prevention that would not be prevented under selective/indicated for minority vs. non-Hispanic white people), (4) quantitative and qualitative measures of scalability (from 98 agencies previously implementing ROSE), (5) ROSE mechanisms across risk levels. We will integrate results to outline pros and cons of the three prevention approaches (i.e., universal, selective, indicated).
conclusionThis will be the first trial to assess universal vs. selective/indicated PPD prevention. Trial design illustrates a novel, efficient way to make these comparisons. This trial, the largest PPD prevention trial to date, will examine scalability, an understudied area of implementation science.
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