Evidence map›Paper›PMID 37473485›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2023

Electromagnetic source imaging predicts surgical outcome in children with focal cortical dysplasia.

Rupesh Kumar Chikara, Saeed Jahromi, Eleonora Tamilia, Joseph R Madsen, Steve M Stufflebeam, Phillip L Pearl, Christos Papadelis

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Noninvasive Biomarkers for Assessing the Excitatory/Inhibitory Imbalance in Children with Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Rupesh Kumar ChikaraJane and John Justin Institute for Mind Health, Neuroscience Research, Cook Children's Health Care System, Fort Worth, TX, USA; Department of Bioengineering, University of Texas at Arlington, Arlington, TX, USA.
Saeed JahromiJane and John Justin Institute for Mind Health, Neuroscience Research, Cook Children's Health Care System, Fort Worth, TX, USA; Department of Bioengineering, University of Texas at Arlington, Arlington, TX, USA.
Eleonora TamiliaFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Joseph R MadsenDivision of Epilepsy Surgery, Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Steve M StufflebeamAthinoula Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Phillip L PearlDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Christos PapadelisJane and John Justin Institute for Mind Health, Neuroscience Research, Cook Children's Health Care System, Fort Worth, TX, USA; Department of Bioengineering, University of Texas at Arlington, Arlington, TX, USA; School of Medicine, Texas Christian University, Fort Worth, TX, USA. Electronic address: christos.papadelis@cookchildrens.org.
Boston Children's Hospital · USThe University of Texas at Arlington · USHarvard University · USTexas Christian University · US

Funding

Interictal High Frequency Oscillations of Epileptogenecity in Pediatric PatientsR01NS104116 · NINDS · COOK CHILDREN'S MEDICAL CENTER · PI PAPADELIS, CHRISTOS · 2019 to 2024
$2.4M
Interictal High Frequency Oscillations of Epileptogenecity in Pediatric PatientsR21NS101373 · NINDS · COOK CHILDREN'S MEDICAL CENTER · PI PAPADELIS, CHRISTOS, STUFFLEBEAM, STEVEN · 2018 to 2019
$501k
NINDS NIH HHS R01 NS104116NINDS NIH HHS R21 NS101373
6 · The paper itself

Abstract

objectiveTo evaluate the diagnostic accuracy of electromagnetic source imaging (EMSI) in localizing spikes and predict surgical outcome in children with drug resistant epilepsy (DRE) due to focal cortical dysplasia (FCD).

methodsWe retrospectively analyzed magnetoencephalography (MEG) and high-density (HD-EEG) data from 23 children with FCD-associated DRE who underwent intracranial EEG and surgery. We localized spikes using equivalent current dipole (ECD) fitting, dipole clustering, and dynamical statistical parametric mapping (dSPM) on EMSI, electric source imaging (ESI), and magnetic source imaging (MSI). We calculated the distance from the seizure onset zone (D

resultsEMSI presented shorter D

conclusionsEMSI provides superior localization and improved predictive performance than individual modalities. SIGNIFICANCE: EMSI can help the surgical planning and facilitate the localization of epileptogenic foci.

Indexed as

Drug Resistant EpilepsyEpilepsyFocal Cortical DysplasiaChildElectroencephalographyElectromagnetic PhenomenaHumansMagnetic Resonance ImagingMagnetoencephalographyRetrospective StudiesTreatment OutcomeElectromagnetic source imagingEpilepsy surgeryFocal cortical dysplasiaIntracranial EEGIrritative zoneSeizure onset zone

Identifiers

PMID37473485
PMCPMC10528204
OpenAlexW4383199445

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.