Evidence map›Paper›PMID 37471538›Full record

ArticleScience (New York, N.Y.)2023

Genomic assessment of invasion dynamics of SARS-CoV-2 Omicron BA.1.

Joseph L-H Tsui, John T McCrone, Ben Lambert, Sumali Bajaj, Rhys P D Inward, Paolo Bosetti, Rosario Evans Pena, Houriiyah Tegally, Verity Hill, Alexander E Zarebski and 31 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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  9. SARS-CoV-2 mutant spectrum complexity is an epidemiologically evolvable trait.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Tracing SARS-CoV-2 clusters across local scales using genomic data.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Joseph L-H TsuiDepartment of Biology, University of Oxford, Oxford, UK.ORCID 0000-0001-7871-8627
John T McCrone *Institute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-9846-8917
Ben Lambert *College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK.ORCID 0000-0003-4274-4158
Sumali Bajaj *Department of Biology, University of Oxford, Oxford, UK.ORCID 0000-0002-8313-819X
Rhys P D Inward *Department of Biology, University of Oxford, Oxford, UK.ORCID 0000-0003-0016-661X
Paolo Bosetti *Institut Pasteur, Université Paris Cité, CNRS, Paris, France.ORCID 0000-0001-7078-7118
Rosario Evans Pena *Department of Biology, University of Oxford, Oxford, UK.
Houriiyah TegallyKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.ORCID 0000-0002-7102-8540
Verity HillInstitute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK.
Alexander E ZarebskiDepartment of Biology, University of Oxford, Oxford, UK.ORCID 0000-0003-1824-7653
Thomas P PeacockDepartment of Infectious Disease, Imperial College London, London, UK.ORCID 0000-0001-7077-2928
Luyang LiuGoogle Research, Mountain View, CA 94043, USA.
Neo WuGoogle Research, Mountain View, CA 94043, USA.ORCID 0000-0003-2389-9584
Megan DavisBlueDot, Toronto, Canada.ORCID 0000-0002-3064-6705
Isaac I BogochDepartment of Medicine, Division of Infectious Diseases, University of Toronto, Toronto, Canada.ORCID 0000-0003-1590-6748
Kamran KhanBlueDot, Toronto, Canada.ORCID 0000-0003-4367-960X
Meaghan KallUK Health Security Agency, London, UK.ORCID 0000-0001-6971-427X
Nurin Iwani Binti Abdul AzizUK Health Security Agency, London, UK.ORCID 0000-0002-8098-6935
Rachel ColquhounInstitute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-5577-9897
Áine O'TooleInstitute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-8083-474X
Ben JacksonInstitute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-9981-0649
Abhishek DasguptaDepartment of Biology, University of Oxford, Oxford, UK.ORCID 0000-0003-4420-0656
Eduan WilkinsonKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.ORCID 0000-0002-2503-9441
Tulio de OliveiraKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.ORCID 0000-0002-3027-5254
COVID-19 Genomics UK (COG-UK) consortium¶
Thomas R ConnorPathogen Genomics Unit, Public Health Wales NHS Trust, Cardiff, UK.ORCID 0000-0003-2394-6504
Nicholas J LomanInstitute of Microbiology and Infection, University of Birmingham, Birmingham, UK.ORCID 0000-0002-9843-8988
Vittoria ColizzaSorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP), Paris, France.ORCID 0000-0002-2113-2374
Christophe FraserBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, UK.ORCID 0000-0003-2399-9657
Erik VolzMRC Centre of Global Infectious Disease Analysis, Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK.ORCID 0000-0001-6268-8937
Xiang JiDepartment of Mathematics, Tulane University, New Orleans, LA 70118, USA.ORCID 0000-0002-7243-0865
Bernardo GutierrezDepartment of Biology, University of Oxford, Oxford, UK.ORCID 0000-0002-9220-2739
Meera ChandUK Health Security Agency, London, UK.
Simon DellicourSpatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Bruxelles, Belgium.ORCID 0000-0001-9558-1052
Simon Cauchemez *Institut Pasteur, Université Paris Cité, CNRS, Paris, France.ORCID 0000-0001-9186-4549
Jayna Raghwani *Department of Biology, University of Oxford, Oxford, UK.ORCID 0000-0001-8538-4995
Marc A Suchard *Departments of Biostatistics, Biomathematics and Human Genetics, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0001-9818-479X
Philippe Lemey *Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.ORCID 0000-0003-2826-5353
Andrew Rambaut *Institute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-4337-3707
Oliver G Pybus *Department of Biology, University of Oxford, Oxford, UK.ORCID 0000-0002-8797-2667
Moritz U G Kraemer *Department of Biology, University of Oxford, Oxford, UK.ORCID 0000-0001-8838-7147

Funding

University of Washington Arboviral Research Network (UWARN)U01AI151698 · NIAID · UNIVERSITY OF WASHINGTON · PI Michael Gale, PETER MACGARR RABINOWITZ · 2020 to 2026
$13.3M
Role of Data Streams In Informing Infection Dynamics in Africa- INFORM AfricaU54TW012041 · FIC · INSTITUTE OF HUMAN VIROLOGY · PI Alash'le G. Abimiku, Tulio de Paiva Nazareth Andrade De Oliveira · 2021 to 2026
$6.9M
Fast and flexible Bayesian phylogenetics via modern machine learningR01AI162611 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MATSEN, FREDERICK ALBERT · 2021 to 2025
$3.8M
Statistical Innovation to Integrate Sequences and Phenotypes for Scalable Phylodynamic InferenceR01AI153044 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Marc A. Suchard · 2021 to 2026
$2.4M
FIC NIH HHS U54 TW012041Medical Research Council MC_PC_19027NIAID NIH HHS R01 AI153044NIAID NIH HHS R01 AI162611NIAID NIH HHS U01 AI151698Wellcome Trust
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) now arise in the context of heterogeneous human connectivity and population immunity. Through a large-scale phylodynamic analysis of 115,622 Omicron BA.1 genomes, we identified >6,000 introductions of the antigenically distinct VOC into England and analyzed their local transmission and dispersal history. We find that six of the eight largest English Omicron lineages were already transmitting when Omicron was first reported in southern Africa (22 November 2021). Multiple datasets show that importation of Omicron continued despite subsequent restrictions on travel from southern Africa as a result of export from well-connected secondary locations. Initiation and dispersal of Omicron transmission lineages in England was a two-stage process that can be explained by models of the country's human geography and hierarchical travel network. Our results enable a comparison of the processes that drive the invasion of Omicron and other VOCs across multiple spatial scales.

Indexed as

COVID-19SARS-CoV-2Africa, SouthernGenomicsHumansPhylogeny

Identifiers

PMID37471538
PMCPMC10866301

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.